Ann Bode, Ph.D.
Professor
Cancer Biomarkers & Drug Resistance
and
Cellular & Molecular Biology
507-437-9615
ambode@hi.umn.edu

Ann M. Bode is the Associate Director of The Hormel Institute and leader of Biomarkers and Drug Resistance and co-leader of Molecular and Cellular Biology research sections at The Hormel Institute. Dr. Bode received her B.S. and M.S. from Southern Illinois University and her Ph.D. from the University of Oregon. She did her post-doctoral work in the Department of Biochemistry in the School of Medicine at the University of North Dakota. She was a full-time tenured faculty member in the Department of Physiology in the School of Medicine where she was Director of Graduate Studies, Head of Cardiovascular Physiology for First Year Medical Students, and ran a research program specializing in the role of reactive oxygen species and antioxidants in chronic diseases, including cancer and diabetes.  Prior to receiving her Ph.D., Dr. Bode spent many years as a college women’s athletic director and volleyball coach.

 

 

Education

B.S. Southern Illinois University, Carbondale, Illinois Physical Education
M.S.  Southern Illinois University, Carbondale, Illinois  Kinesiology
Ph.D.  University of Oregon, Eugene, Oregon Applied Physiology with Anatomy and Biochemistry as second areas of study
 Post-doc  University of North Dakota, Grand Forks, ND  Biochemistry

Professional memberships

American Association for Cancer Research

-University of Minnesota Cancer Center

-Ad hoc NIH study section participant SBIR, DMP, CDP, Minority Fellowship Training 2005-current

-Member-Special Emphasis Panel-NIH PREVENT Program

-Reviewer for L’Oreal USA Fellowships For Women in Science 2008-current

 

Research Interests

-Molecular mechanisms of carcinogenesis and chemoprevention of cancer

-Signal transduction pathways (MAP kinases, S6 kinases) and transcription factors (AP-1, NF-kB, NFAT, p53) in development, and disease

-Molecular mechanisms of chemopreventive effect of natural dietary compounds especially [6]-gingerol, tea polyphenols and resveratrol

-Targeting transcription factors for cancer prevention and treatment

-Oxidative stress, ultraviolet, arsenic and other environmental human carcinogen-induced signal transduction pathways and carcinogenesis

-Cancer biomarkers and drug resistance.

 

Publications (from most recent)

1.         Bode, A.M., et al. (2015) Toxic Phytochemicals and Their Potential Risks for Human Cancer. Cancer Prev Res (Phila), 8, 1-8.

2.         Yu, X., et al. (2014) Neoalbaconol induces cell death through necroptosis by regulating RIPK-dependent autocrine TNFalpha and ROS production. Oncotarget.

3.         Yao, K., et al. (2014) JNK1 and 2 play a negative role in reprogramming to pluripotent stem cells by suppressing Klf4 activity. Stem Cell Res, 12, 139-52.

4.         Yao, K., et al. (2014) Kaempferol targets RSK2 and MSK1 to suppress UV radiation-induced skin cancer. Cancer Prev Res (Phila), 7, 958-67.

5.         Yao, K., et al. (2014) Licochalcone A, a natural inhibitor of c-Jun N-terminal kinase 1. Cancer prevention research, 7, 139-49.

6.         Yang, G., et al. (2014) Caffeic acid directly targets ERK1/2 to attenuate solar UV-induced skin carcinogenesis. Cancer Prev Res (Phila), 7, 1056-66.

7.         Xiao, L., et al. (2014) Targeting Epstein-Barr virus oncoprotein LMP1-mediated glycolysis sensitizes nasopharyngeal carcinoma to radiation therapy. Oncogene, 33, 4568-78.

8.         Wu, Y., et al. (2014) A combination of paclitaxel and siRNA-mediated silencing of Stathmin inhibits growth and promotes apoptosis of nasopharyngeal carcinoma cells. Cellular oncology, 37, 53-67.

9.         Wen, W., et al. (2014) Knockdown of RNF2 induces apoptosis by regulating MDM2 and p53 stability. Oncogene, 33, 421-8.

10.        Shin, D.J., et al. (2014) 20-O-beta-D-glucopyranosyl-20(S)-protopanaxadiol suppresses UV-Induced MMP-1 expression through AMPK-mediated mTOR inhibition as a downstream of the PKA-LKB1 pathway. J Cell Biochem, 115, 1702-11.

11.        Sheng, Y., et al. (2014) 3,6,2′,4′,5′-Pentahydroxyflavone, an orally bioavailable multiple protein kinase inhibitor, overcomes gefitinib resistance in non-small cell lung cancer. J Biol Chem, 289, 28192-201.

12.        Oi, N., et al. (2014) Resveratrol induces apoptosis by directly targeting Ras-GTPase-activating protein SH3 domain-binding protein 1. Oncogene.

13.        Nicastro, H.L., et al. (2014) Preventive effects of NSAIDs, NO-NSAIDs, and NSAIDs plus difluoromethylornithine in a chemically induced urinary bladder cancer model. Cancer Prev Res (Phila), 7, 246-54.

14.        Liu, K., et al. (2014) Eupafolin suppresses prostate cancer by targeting phosphatidylinositol 3-kinase-mediated Akt signaling. Mol Carcinog.

15.        Liu, H., et al. (2014) A derivative of chrysin suppresses two-stage skin carcinogenesis by inhibiting mitogen- and stress-activated kinase 1. Cancer Prev Res (Phila), 7, 74-85.

16.        Lim, T.G., et al. (2014) Curcumin suppresses proliferation of colon cancer cells by targeting CDK2. Cancer Prev Res (Phila), 7, 466-74.

17.        Lim, T.G., et al. (2014) The daidzein metabolite, 6,7,4′-Trihydroxyisoflavone, is a novel inhibitor of PKCalpha in suppressing solar UV-induced matrix metalloproteinase 1. Int J Mol Sci, 15, 21419-32.

18.        Lim do, Y., et al. (2014) (+)-2-(1-Hydroxyl-4-oxocyclohexyl) ethyl caffeate suppresses solar UV-induced skin carcinogenesis by targeting PI3K, ERK1/2, and p38. Cancer Prev Res (Phila), 7, 856-65.

19.        Li, H., et al. (2014) 6-C-(E-phenylethenyl)-naringenin suppresses colorectal cancer growth by inhibiting cyclooxygenase-1. Cancer Res, 74, 243-52.

20.        Kim, S.H., et al. (2014) ERK1 phosphorylates Nanog to regulate protein stability and stem cell self-renewal. Stem cell research, 13, 1-11.

21.        Kim, M.S., et al. (2014) Src is a novel potential off-target of RXR agonists, 9-cis-UAB30 and Targretin, in human breast cancer cells. Mol Carcinog.

22.        Kim, M.S., et al. (2014) Naproxen induces cell-cycle arrest and apoptosis in human urinary bladder cancer cell lines and chemically induced cancers by targeting PI3K. Cancer Prev Res (Phila), 7, 236-45.

23.        Kim, M.O., et al. (2014) [6]-shogaol inhibits growth and induces apoptosis of non-small cell lung cancer cells by directly regulating Akt1/2. Carcinogenesis, 35, 683-91.

24.        Kang, S., et al. (2014) The ginsenoside 20-O-beta-D-glucopyranosyl-20(S)-protopanaxadiol induces autophagy and apoptosis in human melanoma via AMPK/JNK phosphorylation. PLoS One, 9, e104305.

25.        Kang, S., et al. (2014) Hirsutenone in Alnus extract inhibits akt activity and suppresses prostate cancer cell proliferation. Mol Carcinog.

26.        Jung, S.K., et al. (2014) Butein, a novel dual inhibitor of MET and EGFR, overcomes gefitinib-resistant lung cancer growth. Mol Carcinog.

27.        Jung, S.K., et al. (2014) Isoliquiritigenin Induces Apoptosis and Inhibits Xenograft Tumor Growth of Human Lung Cancer Cells by Targeting Both Wild Type and L858R/T790M Mutant EGFR. J Biol Chem, 289, 35839-48.

28.        Jung, S.K., et al. (2014) The P110 subunit of PI3-K is a therapeutic target of acacetin in skin cancer. Carcinogenesis, 35, 123-30.

29.        Hu, Z.Y., et al. (2014) Glycolytic genes in cancer cells are more than glucose metabolic regulators. J Mol Med (Berl), 92, 837-45.

30.        Fu, Y., et al. (2014) Antioxidants decrease the apoptotic effect of 5-Fu in colon cancer by regulating Src-dependent caspase-7 phosphorylation. Cell Death Dis, 5, e983.

31.        Duan, Z., et al. (2014) Activation of the Ig Ialpha1 promoter by the transcription factor Ets-1 triggers Ig Ialpha1-Calpha1 germline transcription in epithelial cancer cells. Cell Mol Immunol, 11, 197-205.

32.        De Luca, A., et al. (2014) Src and CXCR4 are involved in the invasiveness of breast cancer cells with acquired resistance to lapatinib. Cell Cycle, 13, 148-56.

33.        Yu, X., et al. (2013) The role of necroptosis, an alternative form of cell death, in cancer therapy. Expert review of anticancer therapy, 13, 883-93.

34.        Xu, J., et al. (2013) Tyrosylprotein sulfotransferase-1 and tyrosine sulfation of chemokine receptor 4 are induced by epstein-barr virus encoded latent membrane protein 1 and associated with the metastatic potential of human nasopharyngeal carcinoma. PloS one, 8, e56114.

35.        Xie, H., et al. (2013) Identification of an Aurora kinase inhibitor specific for the Aurora B isoform. Cancer research, 73, 716-24.

36.        Xie, H., et al. (2013) Discovery of the novel mTOR inhibitor and its antitumor activities in vitro and in vivo. Molecular cancer therapeutics, 12, 950-8.

37.        Song, N.R., et al. (2013) Isoangustone A, A Novel Licorice Compound, Inhibits Cell Proliferation by Targeting PI3K, MKK4, and MKK7 in Human Melanoma. Cancer prevention research, 6, 1293-303.

38.        Lubet, R.A., et al. (2013) Effect of intermittent dosing regimens of erlotinib on methylnitrosourea-induced mammary carcinogenesis. Cancer prevention research, 6, 448-54.

39.        Lu, Y., et al. (2013) Concordant effects of aromatase inhibitors on gene expression in ER+ Rat and human mammary cancers and modulation of the proteins coded by these genes. Cancer prevention research, 6, 1151-61.

40.        Liu, X., et al. (2013) Regulation of microRNAs by epigenetics and their interplay involved in cancer. Journal of experimental & clinical cancer research : CR, 32, 96.

41.        Liu, S., et al. (2013) (-)-Epigallocatechin-3-gallate inhibition of Epstein-Barr virus spontaneous lytic infection involves ERK1/2 and PI3-K/Akt signaling in EBV-positive cells. Carcinogenesis, 34, 627-37.

42.        Liu, K., et al. (2013) Sunlight UV-induced skin cancer relies upon activation of the p38alpha signaling pathway. Cancer research, 73, 2181-8.

43.        Liu, H., et al. (2013) A Chrysin Derivative Suppresses Skin Cancer Growth by Inhibiting Cyclin-dependent Kinases. The Journal of biological chemistry, 288, 25924-37.

44.        Lim, T.G., et al. (2013) MLK3 is a direct target of biochanin A, which plays a role in solar UV-induced COX-2 expression in human keratinocytes. Biochemical pharmacology, 86, 896-903.

45.        Li, W., et al. (2013) TRAF4 Is a Critical Molecule for Akt Activation in Lung Cancer. Cancer research, 73, 6938-50.

46.        Li, J., et al. (2013) Quercetin-3-methyl ether inhibits lapatinib-sensitive and -resistant breast cancer cell growth by inducing G(2)/M arrest and apoptosis. Molecular carcinogenesis, 52, 134-43.

47.        Li, H., et al. (2013) Select dietary phytochemicals function as inhibitors of COX-1 but not COX-2. PloS one, 8, e76452.

48.        Lee, S.Y., et al. (2013) Esculetin Suppresses Proliferation of Human Colon Cancer Cells by Directly Targeting beta-Catenin. Cancer prevention research, 6, 1356-64.

49.        Lee, M.H., et al. (2013) Direct targeting of MEK1/2 and RSK2 by silybin induces cell-cycle arrest and inhibits melanoma cell growth. Cancer prevention research, 6, 455-65.

50.        Lee, M.H., et al. (2013) Tumor suppressor p16(INK4a) inhibits cancer cell growth by downregulating eEF1A2 through a direct interaction. Journal of cell science, 126, 1744-52.

51.        Kim, D.J., et al. (2013) CInQ-03, a novel allosteric MEK inhibitor, suppresses cancer growth in vitro and in vivo. Carcinogenesis, 34, 1134-43.

52.        Keum, Y.S., et al. (2013) UVB-induced COX-2 expression requires histone H3 phosphorylation at Ser10 and Ser28. Oncogene, 32, 444-52.

53.        Hwang, J.A., et al. (2013) 20-O-beta-d-glucopyranosyl-20(S)-protopanaxadiol, a metabolite of ginseng, inhibits colon cancer growth by targeting TRPC channel-mediated calcium influx. The Journal of nutritional biochemistry, 24, 1096-104.

54.        Deng, Q., et al. (2013) Neoalbaconol induces energy depletion and multiple cell death in cancer cells by targeting PDK1-PI3-K/Akt signaling pathway. Cell death & disease, 4, e804.

55.        Cho, Y.Y., et al. (2013) Autophagy and cellular senescence mediated by sox2 suppress malignancy of cancer cells. PloS one, 8, e57172.

56.        Byun, S., et al. (2013) USP8 Is a Novel Target for Overcoming Gefitinib Resistance in Lung Cancer. Clinical cancer research : an official journal of the American Association for Cancer Research, 19, 3894-3904.

57.        Bode, A.M., et al. (2013) Signal transduction and molecular targets of selected flavonoids. Antioxidants & redox signaling, 19, 163-80.

58.        Baek, S., et al. (2013) Structural and functional analysis of the natural JNK1 inhibitor quercetagetin. Journal of molecular biology, 425, 411-23.

59.        Zhao, L., et al. (2012) Regulatory mechanisms and clinical perspectives of miRNA in tumor radiosensitivity. Carcinogenesis, 33, 2220-7.

60.        Zhang, J., et al. (2012) Rack1 protects N-terminal phosphorylated c-Jun from Fbw7-mediated degradation. Oncogene, 31, 1835-44.

61.        Xie, H., et al. (2012) Identification of mammalian target of rapamycin as a direct target of fenretinide both in vitro and in vivo. Carcinogenesis, 33, 1814-21.

62.        Peng, C., et al. (2012) Tumor necrosis factor receptor-associated factor family protein 2 is a key mediator of the epidermal growth factor-induced ribosomal S6 kinase 2/cAMP-responsive element-binding protein/Fos protein signaling pathway. The Journal of biological chemistry, 287, 25881-92.

63.        Oi, N., et al. (2012) Taxifolin Suppresses UV-Induced Skin Carcinogenesis by Targeting EGFR and PI3K. Cancer prevention research, 5, 1103-14.

64.        Liu, K., et al. (2012) Aloe-emodin suppresses prostate cancer by targeting the mTOR complex 2. Carcinogenesis, 33, 1406-11.

65.        Liu, H., et al. (2012) EBV-encoded LMP1 upregulates Igkappa 3’enhancer activity and Igkappa expression in nasopharyngeal cancer cells by activating the Ets-1 through ERKs signaling. PloS one, 7, e32624.

66.        Li, Z., et al. (2012) EBV encoded miR-BHRF1-1 potentiates viral lytic replication by downregulating host p53 in nasopharyngeal carcinoma. The international journal of biochemistry & cell biology, 44, 275-9.

67.        Li, X., et al. (2012) Ceftriaxone, an FDA-approved cephalosporin antibiotic, suppresses lung cancer growth by targeting Aurora B. Carcinogenesis, 33, 2548-57.

68.        Li, M., et al. (2012) Promotion of cell proliferation and inhibition of ADCC by cancerous immunoglobulin expressed in cancer cell lines. Cellular & molecular immunology, 9, 54-61.

69.        Li, J., et al. (2012) Quercetin-3-methyl ether suppresses proliferation of mouse epidermal JB6 P+ cells by targeting ERKs. Carcinogenesis, 33, 459-65.

70.        Li, J., et al. (2012) Norathyriol suppresses skin cancers induced by solar ultraviolet radiation by targeting ERK kinases. Cancer research, 72, 260-70.

71.        Lee, S.Y., et al. (2012) The Role of Heterodimeric AP-1 Protein Comprised of JunD and c-Fos Proteins in Hematopoiesis. The Journal of biological chemistry, 287, 31342-8.

72.        Kim, M.O., et al. (2012) ERK1 and ERK2 regulate embryonic stem cell self-renewal through phosphorylation of Klf4. Nature structural & molecular biology, 19, 283-90.

73.        Kim, H.G., et al. (2012) Polycomb (PcG) Proteins, BMI1 and SUZ12, Regulate Arsenic-induced Cell Transformation. The Journal of biological chemistry, 287, 31920-8.

74.        Kim, D.J., et al. (2012) Novel TOPK inhibitor HI-TOPK-032 effectively suppresses colon cancer growth. Cancer research, 72, 3060-8.

75.        He, Z., et al. (2012) Analysis of the role of p38 MAP kinase in epidermal growth factor-induced JB6 Cl41 cell transformation by cDNA array. Gene, 497, 71-8.

76.        Guo, L., et al. (2012) Epstein-Barr virus oncoprotein LMP1 mediates survivin upregulation by p53 contributing to G1/S cell cycle progression in nasopharyngeal carcinoma. International journal of molecular medicine, 29, 574-80.

77.        Cho, Y.Y., et al. (2012) RSK2 as a key regulator in human skin cancer. Carcinogenesis, 33, 2529-37.

78.        Chen, H., et al. (2012) Prediction of molecular targets of cancer preventing flavonoid compounds using computational methods. PloS one, 7, e38261.

79.        Bode, A.M., et al. (2012) Effects of Dietary Effectors on Signal Transduction Pathways Related to Cancer Prevention. In Bidlack, W.R., et al. (eds.), Nutritional Genomics–The Impact of Dietary Regulation of Gene Function on Human Disease. CRC Press, New York, pp. 243-268.

80.        Zhu, F., et al. (2011) Phosphorylation of H2AX at Ser139 and a new phosphorylation site Ser16 by RSK2 decreases H2AX ubiquitination and inhibits cell transformation. Cancer Res, 71, 393-403.

81.        Urusova, D.V., et al. (2011) Epigallocatechin-gallate suppresses tumorigenesis by directly targeting Pin1. Cancer prevention research, 4, 1366-77.

82.        Rouzer, C.A., et al. (2011) Green tea gets molecular. Cancer prevention research, 4, 1343-5.

83.        Peng, C., et al. (2011) Phosphorylation of caspase-8 (Thr-263) by ribosomal S6 kinase 2 (RSK2) mediates caspase-8 ubiquitination and stability. J Biol Chem, 286, 6946-54.

84.        Luo, X.J., et al. (2011) DAPK1 mediates the G1 phase arrest in human nasopharyngeal carcinoma cells induced by grifolin, a potential antitumor natural product. European journal of pharmacology, 670, 427-34.

85.        Lubet, R.A., et al. (2011) Efficacy of the EGFr inhibitor Iressa on development of chemically-induced urinary bladder cancers: Dose dependency and modulation of biomarkers. Oncol Rep, 25, 1389-97.

86.        Liu, K., et al. (2011) Eriodictyol inhibits RSK2-ATF1 signaling and suppresses EGF-induced neoplastic cell transformation. J Biol Chem, 286, 2057-66.

87.        Li, Y., et al. (2011) Discovery of novel checkpoint kinase 1 inhibitors by virtual screening based on multiple crystal structures. Journal of chemical information and modeling, 51, 2904-14.

88.        Li, X., et al. (2011) Phosphorylation of Caspase-7 by p21-activated Protein Kinase (PAK) 2 Inhibits Chemotherapeutic Drug-induced Apoptosis of Breast Cancer Cell Lines. J Biol Chem, 286, 22291-9.

89.        Li, T., et al. (2011) P21-activated protein kinase (PAK2)-mediated c-Jun phosphorylation at 5 threonine sites promotes cell transformation. Carcinogenesis, 32, 659-66.

90.        Li, S., et al. (2011) T-LAK cell-originated protein kinase (TOPK) phosphorylation of MKP1 protein prevents solar ultraviolet light-induced inflammation through inhibition of the p38 protein signaling pathway. The Journal of biological chemistry, 286, 29601-9.

91.        Li, S., et al. (2011) TRPV1-antagonist AMG9810 promotes mouse skin tumorigenesis through EGFR/Akt signaling. Carcinogenesis, 32, 779-85.

92.        Li, J., et al. (2011) Lapatinib, a Preventive/Therapeutic Agent against Mammary Cancer, Suppresses RTK-Mediated Signaling through Multiple Signaling Pathways. Cancer Prev Res (Phila), 4, 1190-7.

93.        Lee, K.W., et al. (2011) Molecular targets of phytochemicals for cancer prevention. Nat Rev Cancer, 11, 211-8.

94.        Lee, D.E., et al. (2011) 6,7,4′-trihydroxyisoflavone inhibits HCT-116 human colon cancer cell proliferation by targeting CDK1 and CDK2. Carcinogenesis, 32, 629-35.

95.        Lee, D.E., et al. (2011) 7,3′,4′-Trihydroxyisoflavone, a metabolite of the soy isoflavone daidzein, suppresses ultraviolet B-induced skin cancer by targeting Cot and MKK4. J Biol Chem, 286, 14246-56.

96.        Lau, A.T., et al. (2011) Phosphorylation of Histone H2B Serine 32 Is Linked to Cell Transformation. J Biol Chem, 286, 26628-37.

97.        Kim, M.O., et al. (2011) Embryonic stem-cell-preconditioned microenvironment induces loss of cancer cell properties in human melanoma cells. Pigment cell & melanoma research, 24, 922-31.

98.        Kim, J.E., et al. (2011) Isorhamnetin Suppresses Skin Cancer through Direct Inhibition of MEK1 and PI3-K. Cancer Prev Res (Phila), 4, 582-91.

99.        Kim, D.J., et al. (2011) (3-Chloroacetyl)-indole, a Novel Allosteric AKT Inhibitor, Suppresses Colon Cancer Growth In Vitro and In Vivo. Cancer prevention research, 4, 1842-51.

100.      Kang, N.J., et al. (2011) Coffee phenolic phytochemicals suppress colon cancer metastasis by targeting MEK and TOPK. Carcinogenesis, 32, 921-8.

101.      Hu, D., et al. (2011) Heterogeneity of aberrant immunoglobulin expression in cancer cells. Cellular & molecular immunology, 8, 479-85.

102.      Hoenerhoff, M.J., et al. (2011) Pathologic progression of mammary carcinomas in a C3(1)/SV40 T/t-antigen transgenic rat model of human triple-negative and Her2-positive breast cancer. Transgenic Res, 20, 247-59.

103.      Bode, A.M., et al. (2011) The Amazing and Mighty Ginger. In Benzie, I.F.F., et al. (eds.), Herbal Medicine–Biomolecular and Clinical Aspects. CRC Press–Taylor and Francis Group, New York, pp. 131-156.

104.      Bode, A.M., et al. (2011) The two faces of capsaicin. Cancer Res, 71, 2809-14.

105.      Zykova, T.A., et al. (2010) T-LAK cell-originated protein kinase (TOPK) phosphorylation of Prx1 at Ser-32 prevents UVB-induced apoptosis in RPMI7951 melanoma cells through the regulation of Prx1 peroxidase activity. J Biol Chem, 285, 29138-46.

106.      Xu, Y.M., et al. (2010) Extracellular signal-regulated kinase 8-mediated c-Jun phosphorylation increases tumorigenesis of human colon cancer. Cancer Res, 70, 3218-27.

107.      Wen, W., et al. (2010) MST1 promotes apoptosis through phosphorylation of histone H2AX. J Biol Chem, 285, 39108-16.

108.      Surh, Y.J., et al. (2010) Breaking the NF-{kappa}B and STAT3 alliance inhibits inflammation and pancreatic tumorigenesis. Cancer Prev Res (Phila), 3, 1379-81.

109.      Shim, J.H., et al. (2010) Epigallocatechin gallate suppresses lung cancer cell growth through Ras-GTPase-activating protein SH3 domain-binding protein 1. Cancer Prev Res (Phila), 3, 670-9.

110.      Peng, C., et al. (2010) RSK2 mediates NF-{kappa}B activity through the phosphorylation of IkappaBalpha in the TNF-R1 pathway. FASEB J, 24, 3490-9.

111.      Oi, N., et al. (2010) Resveratrol, a red wine polyphenol, suppresses pancreatic cancer by inhibiting leukotriene a4 hydrolase. Cancer Res, 70, 9755-64.

112.      Malakhova, M., et al. (2010) The crystal structure of the active form of the C-terminal kinase domain of mitogen- and stress-activated protein kinase 1. J Mol Biol, 399, 41-52.

113.      Lee, S.Y., et al. (2010) Histone XH2AX is required for Xenopus anterior neural development: critical role of threonine 16 phosphorylation. J Biol Chem, 285, 29525-34.

114.      Lee, K.M., et al. (2010) Kaempferol inhibits UVB-induced COX-2 expression by suppressing Src kinase activity. Biochem Pharmacol, 80, 2042-9.

115.      Lee, K.M., et al. (2010) 5-deoxykaempferol plays a potential therapeutic role by targeting multiple signaling pathways in skin cancer. Cancer Prev Res (Phila Pa), 3, 454-65.

116.      Lee, D.E., et al. (2010) 7,3′,4′-Trihydroxyisoflavone inhibits epidermal growth factor-induced proliferation and transformation of JB6 P+ mouse epidermal cells by suppressing cyclin-dependent kinases and phosphatidylinositol 3-kinase. J Biol Chem, 285, 21458-66.

117.      Jung, S.K., et al. (2010) Myricetin suppresses UVB-induced wrinkle formation and MMP-9 expression by inhibiting Raf. Biochem Pharmacol, 79, 1455-61.

118.      Jung, S.K., et al. (2010) Myricetin inhibits UVB-induced angiogenesis by regulating PI-3 kinase in vivo. Carcinogenesis, 31, 911-7.

119.      Jeong, C.H., et al. (2010) Phosphorylation of sox2 cooperates in reprogramming to pluripotent stem cells. Stem Cells, 28, 2141-50.

120.      Jeon, Y.J., et al. (2010) Role of NEK6 in tumor promoter-induced transformation in JB6 C141 mouse skin epidermal cells. J Biol Chem, 285, 28126-33.

121.      Hwang, M.K., et al. (2010) Cocarcinogenic effect of capsaicin involves activation of EGFR signaling but not TRPV1. Cancer Res, 70, 6859-69.

122.      Fritz, V., et al. (2010) Glucosinolate Enhancement in Cabbage Induced by Jasmonic Acid Application. HortScience, 45, 1188-1191.

123.      Fedorov, S., et al. (2010) The anticancer effects of actinoporin RTX-A from the sea anemone Heteractis crispa (=Radianthus macrodactylus). Toxicon, 55, 811-7.

124.      Byun, S., et al. (2010) Luteolin inhibits protein kinase C(epsilon) and c-Src activities and UVB-induced skin cancer. Cancer Res, 70, 2415-23.

125.      Bode, A.M., et al. (2010) Update on cancer prevention research in the United States and china: the 2009 china–u.s. Forum on frontiers of cancer research. Cancer Prev Res (Phila), 3, 1630-7.

126.      Yao, K., et al. (2009) A selective small-molecule inhibitor of c-Jun N-terminal kinase 1. FEBS Lett, 583, 2208-12.

127.      Malakhova, M., et al. (2009) Structural diversity of the active N-terminal kinase domain of p90 ribosomal S6 kinase 2. PLoS One, 4, e8044.

128.      Lee, K.M., et al. (2009) Tpl2 is a key mediator of arsenite-induced signal transduction. Cancer Res, 69, 8043-9.

129.      Kwon, J.Y., et al. (2009) Delphinidin suppresses ultraviolet B-induced cyclooxygenases-2 expression through inhibition of MAPKK4 and PI-3 kinase. Carcinogenesis, 30, 1932-40.

130.      Kang, N.J., et al. (2009) Caffeic acid, a phenolic phytochemical in coffee, directly inhibits Fyn kinase activity and UVB-induced COX-2 expression. Carcinogenesis, 30, 321-30.

131.      Jeong, C.H., et al. (2009) [6]-Gingerol suppresses colon cancer growth by targeting leukotriene A4 hydrolase. Cancer Res, 69, 5584-91.

132.      Choi, H.S., et al. (2009) c-Jun N-terminal kinase 1 phosphorylates Myt1 to prevent UVA-induced skin cancer. Molecular and cellular biology, 29, 2168-80.

133.      Cho, Y.Y., et al. (2009) A regulatory mechanism for RSK2 NH(2)-terminal kinase activity. Cancer Res, 69, 4398-406.

134.      Cho, Y.Y., et al. (2009) Cyclin-dependent kinase-3-mediated c-Jun phosphorylation at Ser63 and Ser73 enhances cell transformation. Cancer Res, 69, 272-81.

135.      Bode, A.M., et al. (2009) Modulation of Cell Signal Transduction by Tea and Ginger. In Surh, Y.-J., et al. (eds.), Dietary Modulation of Cell Signaling Pathways. CRC Press–Taylor & Francis Group, New York, pp. 45-74.

136.      Bode, A.M., et al. (2009) Signal transduction molecules as targets for cancer prevention. Sci Signal, 2, mr2.

137.      Bode, A.M., et al. (2009) Epigallocatechin 3-gallate and green tea catechins: United they work, divided they fail. Cancer Prev Res (Phila Pa), 2, 514-7.

138.      Bode, A.M., et al. (2009) Cancer prevention research – then and now. Nat Rev Cancer, 9, 508-16.

139.      Bode, A.M., et al. (2009) Transient receptor potential type vanilloid 1 suppresses skin carcinogenesis. Cancer Res, 69, 905-13.

140.      Bode, A.M. (2009) In pursuit of a cure: Searching for food-based cancer therapies and preventions at The Hormel Institute. Rural Minnesota Journal, 4, 107-115.

141.      Zykova, T.A., et al. (2008) Resveratrol directly targets COX-2 to inhibit carcinogenesis. Molecular carcinogenesis, 47, 797-805.

142.      Zheng, D., et al. (2008) Cyclin-dependent kinase 3-mediated activating transcription factor 1 phosphorylation enhances cell transformation. Cancer Res, 68, 7650-60.

143.      Zheng, D., et al. (2008) The cannabinoid receptors are required for ultraviolet-induced inflammation and skin cancer development. Cancer Res, 68, 3992-8.

144.      Shim, J.H., et al. (2008) (-)-Epigallocatechin gallate regulates CD3-mediated T cell receptor signaling in leukemia through the inhibition of ZAP-70 kinase. J Biol Chem, 283, 28370-9.

145.      Rogozin, E.A., et al. (2008) Inhibitory effects of caffeine analogues on neoplastic transformation: structure-activity relationship. Carcinogenesis, 29, 1228-34.

146.      Malakhova, M., et al. (2008) Structural basis for activation of the autoinhibitory C-terminal kinase domain of p90 RSK2. Nat Struct Mol Biol, 15, 112-3.

147.      Lubet, R.A., et al. (2008) Effects of gefitinib (Iressa) on mammary cancers: preventive studies with varied dosages, combinations with vorozole or targretin, and biomarker changes. Mol Cancer Ther, 7, 972-9.

148.      Lee, K.W., et al. (2008) The resveratrol analogue 3,5,3′,4′,5′-pentahydroxy-trans-stilbene inhibits cell transformation via MEK. Int J Cancer, 123, 2487-96.

149.      Lee, K.W., et al. (2008) Raf and MEK protein kinases are direct molecular targets for the chemopreventive effect of quercetin, a major flavonol in red wine. Cancer Res, 68, 946-55.

150.      Kim, H.G., et al. (2008) Mitogen- and stress-activated kinase 1-mediated histone H3 phosphorylation is crucial for cell transformation. Cancer Res, 68, 2538-47.

151.      Kang, N.J., et al. (2008) Cocoa procyanidins suppress transformation by inhibiting mitogen-activated protein kinase kinase. The Journal of biological chemistry, 283, 20664-73.

152.      Kang, N.J., et al. (2008) Delphinidin attenuates neoplastic transformation in JB6 Cl41 mouse epidermal cells by blocking Raf/mitogen-activated protein kinase kinase/extracellular signal-regulated kinase signaling. Cancer Prev Res (Phila Pa), 1, 522-31.

153.      Jung, S.K., et al. (2008) Myricetin suppresses UVB-induced skin cancer by targeting Fyn. Cancer Res, 68, 6021-9.

154.      He, Z., et al. (2008) Fyn is a novel target of (-)-epigallocatechin gallate in the inhibition of JB6 Cl41 cell transformation. Mol Carcinog, 47, 172-83.

155.      Fedorov, S.N., et al. (2008) Anticancer activity of 3-demethylubiquinone Q2. In vivo experiments and probable mechanism of action. Anticancer research, 28, 927-32.

156.      Choi, H.S., et al. (2008) Cot, a novel kinase of histone H3, induces cellular transformation through up-regulation of c-fos transcriptional activity. Faseb J, 22, 113-26.

157.      Zykova, T.A., et al. (2007) Involvement of ERKs, RSK2 and PKR in UVA-induced signal transduction toward phosphorylation of eIF2{alpha} (Ser51). Carcinogenesis, 28, 1543-51.

158.      Zhu, F., et al. (2007) Bidirectional signals transduced by TOPK-ERK interaction increase tumorigenesis of HCT116 colorectal cancer cells. Gastroenterology, 133, 219-31.

159.      Yao, K., et al. (2007) Nuclear Factor of Activated T3 Is a Negative Regulator of Ras-JNK1/2-AP-1 Induced Cell Transformation. Cancer Res, 67, 8725-35.

160.      Saari, J.T., et al. (2007) Cardiac nitric oxide synthases are elevated in dietary copper deficiency. The Journal of nutritional biochemistry, 18, 443-8.

161.      Oh, S.M., et al. (2007) T-Lymphokine-Activated Killer Cell-Originated Protein Kinase Functions as a Positive Regulator of c-Jun-NH2-Kinase 1 Signaling and H-Ras-Induced Cell Transformation. Cancer Res, 67, 5186-94.

162.      Li, M., et al. (2007) Direct inhibition of insulin-like growth factor-I receptor kinase activity by (-)-epigallocatechin-3-gallate regulates cell transformation. Cancer Epidemiol Biomarkers Prev, 16, 598-605.

163.      Lee, K.W., et al. (2007) Myricetin is a novel natural inhibitor of neoplastic cell transformation and MEK1. Carcinogenesis, 28, 1918-27.

164.      Kang, N.J., et al. (2007) Equol, a metabolite of the soybean isoflavone daidzein, inhibits neoplastic cell transformation by targeting the MEK/ERK/p90RSK/activator protein-1 pathway. J Biol Chem, 282, 32856-66.

165.      Fedorov, S.N., et al. (2007) Dactylone inhibits epidermal growth factor-induced transformation and phenotype expression of human cancer cells and induces G1-S arrest and apoptosis. Cancer Res, 67, 5914-20.

166.      Cho, Y.Y., et al. (2007) Ribosomal S6 kinase 2 is a key regulator in tumor promoter induced cell transformation. Cancer Res, 67, 8104-12.

167.      Cho, Y.Y., et al. (2007) RSK2 mediates muscle cell differentiation through regulation of NFAT3. J Biol Chem, 282, 8380-92.

168.      Bode, A.M., et al. (2007) The functional contrariety of JNK. Mol Carcinog, 46, 591-8.

169.      Bode, A.M., et al. (2007) The enigmatic effects of caffeine in cell cycle and cancer. Cancer Lett, 247, 26-39.

170.      Zykova, T.A., et al. (2006) Lymphokine-Activated Killer T-Cell-Originated Protein Kinase Phosphorylation of Histone H2AX Prevents Arsenite-Induced Apoptosis in RPMI7951 Melanoma Cells. Clin Cancer Res, 12, 6884-93.

171.      Zhu, F., et al. (2006) COOH-terminal Src kinase-mediated c-Jun phosphorylation promotes c-Jun degradation and inhibits cell transformation. Cancer Res, 66, 5729-36.

172.      Tatsumi, Y., et al. (2006) Involvement of the paxillin pathway in JB6 Cl41 cell transformation. Cancer Res, 66, 5968-74.

173.      Tang, F., et al. (2006) Arsenite inhibits p53 phosphorylation, DNA binding activity, and p53 target gene p21 expression in mouse epidermal JB6 cells. Molecular carcinogenesis, 45, 861-70.

174.      Mizuno, H., et al. (2006) Theaflavin-3, 3′-digallate induces epidermal growth factor receptor downregulation. Mol Carcinog, 45, 204-12.

175.      Mizuno, H., et al. (2006) Effects of MAP kinase inhibitors on epidermal growth factor-induced neoplastic transformation of human keratinocytes. Mol Carcinog, 45, 1-9.

176.      Lu, C., et al. (2006) Cell Apoptosis: Requirement of H2AX in DNA Ladder Formation, but Not for the Activation of Caspase-3. Mol Cell, 23, 121-32.

177.      Fedorov, S.N., et al. (2006) Evaluation of cancer-preventive activity and structure-activity relationships of 3-demethylubiquinone Q2, isolated from the ascidian Aplidium glabrum, and its synthetic analogs. Pharm Res, 23, 70-81.

178.      Ermakova, S.P., et al. (2006) (-)-Epigallocatechin gallate overcomes resistance to etoposide-induced cell death by targeting the molecular chaperone glucose-regulated protein 78. Cancer Res, 66, 9260-9.

179.      Dong, Z., et al. (2006) The role of histone H3 phosphorylation (Ser10 and Ser28) in cell growth and cell transformation. Mol Carcinog, 45, 416-21.

180.      Dong, Z., et al. (2006) Proceedings–targeting carcinogenesis: transduction, transcription, translation. Mol Carcinog, 45, 353-4.

181.      Bode, A.M., et al. (2006) Molecular and cellular targets. Mol Carcinog, 45, 422-30.

182.      Zykova, T.A., et al. (2005) The signal transduction networks required for phosphorylation of STAT1 at Ser727 in mouse epidermal JB6 cells in the UVB response and inhibitory mechanisms of tea polyphenols. Carcinogenesis, 26, 331-42.

183.      Zhao, Q., et al. (2005) 2-Arachidonoylglycerol stimulates activator protein-1-dependent transcriptional activity and enhances epidermal growth factor-induced cell transformation in JB6 P+ cells. J Biol Chem, 280, 26735-42.

184.      Shubina, L.K., et al. (2005) Desmethylubiquinone Q2 from the Far-Eastern ascidian Aplidium glabrum: structure and synthesis. . Tetrahedron Letters 46, 559-562.

185.      He, Z., et al. (2005) Regulation of ultraviolet B-induced phosphorylation of histone H3 at serine 10 by Fyn kinase. J Biol Chem, 280, 2446-54.

186.      Ermakova, S., et al. (2005) The intermediate filament protein vimentin is a new target for epigallocatechin gallate. J Biol Chem, 280, 16882-90.

187.      Dong, Z., et al. (2005) Prevention of Cancer by Dietary Phytochemicals. In Phenolic Compounds in Foods and Natural Health Products. American Chemical Society, Washington D.C., pp. 225-241.

188.      Choi, H.S., et al. (2005) Phosphorylation of Ser28 in histone H3 mediated by mixed lineage kinase-like mitogen-activated protein triple kinase alpha. J Biol Chem, 280, 13545-53.

189.      Choi, H.S., et al. (2005) Phosphorylation of Histone H3 at Serine 10 Is Indispensable for Neoplastic Cell Transformation. Cancer Res, 65, 5818-5827.

190.      Choi, B.Y., et al. (2005) The tumor suppressor p16(INK4a) prevents cell transformation through inhibition of c-Jun phosphorylation and AP-1 activity. Nat Struct Mol Biol, 12, 699-707.

191.      Cho, Y.Y., et al. (2005) The p53 protein is a novel substrate of ribosomal S6 kinase 2 and a critical intermediary for ribosomal S6 kinase 2 and histone H3 interaction. Cancer Res, 65, 3596-603.

192.      Bode, A.M., et al. (2005) Signal transduction pathways in cancer development and as targets for cancer prevention. Prog Nucleic Acid Res Mol Biol, 79, 237-97.

193.      Bode, A.M., et al. (2005) Inducible covalent posttranslational modification of histone H3. Sci STKE, 2005, re4.

194.      Zhu, F., et al. (2004) Involvement of ERKs and mitogen- and stress-activated protein kinase in UVC-induced phosphorylation of ATF2 in JB6 cells. Carcinogenesis, 25, 1847-52.

195.      Hashimoto, T., et al. (2004) Caffeine inhibits cell proliferation by G0/G1 phase arrest in JB6 cells. Cancer Res, 64, 3344-9.

196.      Fedorov, S.N., et al. (2004) Marine alkaloid polycarpine and its synthetic derivative dimethylpolycarpine induce apoptosis in JB6 cells through p53- and caspase 3-dependent pathways. Pharm Res, 21, 2307-19.

197.      Cho, Y.Y., et al. (2004) A novel role for mixed-lineage kinase-like mitogen-activated protein triple kinase alpha in neoplastic cell transformation and tumor development. Cancer Res, 64, 3855-64.

198.      Bode, A.M., et al. (2004) Ginger. In Packer, L., et al. (eds.), Herbal and Traditional Medicine: Molecular Aspects of Health. Marcel Dekker, New York, pp. 165-177.

199.      Bode, A.M., et al. (2004) Post-translational modification of p53 in tumorigenesis. Nature Reviews Cancer, 4, 793-805.

200.      Bode, A.M., et al. (2004) Targeting signal transduction pathways by chemopreventive agents. Mutat Res, 555, 33-51.

201.      Bode, A.M., et al. (2004) Beneficial Effects of Resveratrol. In Bao, Y., et al. (eds.), Phytochemicals in Health and Disease. Marcel Dekker, Inc, New York, vol. 12, pp. 257-284.

202.      Bode, A.M., et al. (2004) Cancer prevention by food factors through targeting signal transduction pathways. Nutrition, 20, 89-94.

203.      Zhang, Y., et al. (2003) Ataxia telangiectasia mutated proteins, MAPKs, and RSK2 are involved in the phosphorylation of STAT3. J Biol Chem, 278, 12650-9.

204.      Liu, G., et al. (2003) NS-398 and Piroxicam Suppress UVB-induced Activator Protein 1 Activity by Mechanisms Independent of Cyclooxygenase-2. J Biol Chem, 278, 2124-30.

205.      Kaji, A., et al. (2003) Pifithrin-alpha promotes p53-mediated apoptosis in JB6 cells. Mol Carcinog, 37, 138-48.

206.      He, Z., et al. (2003) Arsenite-induced phosphorylation of histone H3 at serine 10 is mediated by Akt1, extracellular signal-regulated kinase 2, and p90 ribosomal S6 kinase 2 but not mitogen- and stress-activated protein kinase 1. J Biol Chem, 278, 10588-93.

207.      He, Z., et al. (2003) Induction of apoptosis by caffeine is mediated by the p53, Bax, and caspase 3 pathways. Cancer Res, 63, 4396-401.

208.      He, Z., et al. (2003) p38 Mitogen-activated protein kinase regulation of JB6 Cl41 cell transformation promoted by epidermal growth factor. J Biol Chem, 278, 26435-42.

209.      Dong, Z., et al. (2003) Dialogue between ERKs and JNKs: friendly or antagonistic? Mol Interv, 3, 306-8.

210.      Bode, A.M., et al. (2003) Signal transduction pathways: targets for green and black tea polyphenols. J Biochem Mol Biol, 36, 66-77.

211.      Bode, A.M., et al. (2003) Mitogen-Activated Protein Kinase Activation in UV-Induced Signal Transduction. Sci STKE, 2003, RE2.

212.      Zhang, Y., et al. (2002) Requirement of ATM in UVA-induced signaling and apoptosis. J Biol Chem, 277, 3124-31.

213.      She, Q.B., et al. (2002) Deficiency of c-Jun-NH(2)-terminal kinase-1 in mice enhances skin tumor development by 12-O-tetradecanoylphorbol-13-acetate. Cancer Res, 62, 1343-8.

214.      Liu, G., et al. (2002) Phosphorylation of 4E-BP1 is mediated by the p38/MSK1 pathway in response to UVB irradiation. J Biol Chem, 277, 8810-6.

215.      Chen, N., et al. (2002) Differential gene expression profiles of Jnk1- and Jnk2-deficient murine fibroblast cells. Cancer Res, 62, 1300-4.

216.      Bode, A.M., et al. (2002) Signal transduction pathways: Targets for green and black tea polyphenols. In Pandalai, S.G. (ed.), Recent Research Developments in Cancer. Transworld Research Network, Fort P.O., Trivandrum-696 023, India, vol. 4–Part I, pp. 73-83.

217.      Bode, A.M., et al. (2002) The paradox of arsenic: molecular mechanisms of cell transformation and chemotherapeutic effects. Crit Rev Oncol Hematol, 42, 5-24.

218.      Bode, A.M. (2002) Too much of a good thing? Trends Endocrinol Metab, 13, 139-40.

219.      Zhong, S., et al. (2001) Organ-specific activation of activator protein-1 in transgenic mice by 12-o-tetradecanoylphorbol-13-acetate with different administration methods. Cancer Res, 61, 4084-91.

220.      Zhong, S., et al. (2001) Ultraviolet B-induced phosphorylation of histone H3 at serine 28 is mediated by MSK1. J Biol Chem, 276, 33213-9.

221.      Zhang, Y., et al. (2001) UVA induces Ser381 phosphorylation of p90RSK/MAPKAP-K1 via ERK and JNK pathways. J Biol Chem, 276, 14572-80.

222.      Zhang, Y., et al. (2001) Involvement of the acid sphingomyelinase pathway in uva-induced apoptosis. J Biol Chem, 276, 11775-82.

223.      Zhang, Y., et al. (2001) Signal transduction pathways involved in phosphorylation and activation of p70S6K following exposure to UVA irradiation. J Biol Chem, 276, 20913-23.

224.      Zhang, Y., et al. (2001) Induction of EGFR-dependent and EGFR-independent signaling pathways by ultraviolet A irradiation. DNA Cell Biol, 20, 769-79.

225.      She, Q.B., et al. (2001) Resveratrol-induced activation of p53 and apoptosis is mediated by extracellular-signal-regulated protein kinases and p38 kinase. Cancer Res, 61, 1604-10.

226.      Liu, G., et al. (2001) Proteinase inhibitors I and II from potatoes block UVB-induced AP-1 activity by regulating the AP-1 protein compositional patterns in JB6 cells. Proc Natl Acad Sci U S A, 98, 5786-91.

227.      Liu, G., et al. (2001) Two novel glycosides from the fruits of Morinda citrifolia (noni) inhibit AP-1 transactivation and cell transformation in the mouse epidermal JB6 cell line. Cancer Res, 61, 5749-56.

228.      Liu, G., et al. (2001) Omega 3 but not omega 6 fatty acids inhibit AP-1 activity and cell transformation in JB6 cells. Proc Natl Acad Sci U S A, 98, 7510-5.

229.      Huang, C., et al. (2001) Involvement of sphingomyelinase in insulin-induced phosphatidylinositol 3-kinase activation. Faseb J, 15, 1113-4.

230.      Huang, C., et al. (2001) Transactivation of AP-1 in AP-1-luciferase reporter transgenic mice by arsenite and arsenate. Anticancer Res, 21, 261-7.

231.      Guzman, C.B., et al. (2001) Altered myosin light-chain phosphorylation in resting platelets from premenopausal women with diabetes. Metabolism, 50, 151-6.

232.      Chen, N., et al. (2001) Suppression of skin tumorigenesis in c-Jun NH(2)-terminal kinase-2- deficient mice. Cancer Res, 61, 3908-12.

233.      Chen, N., et al. (2001) Transactivation of the epidermal growth factor receptor is involved in 12-O-tetradecanoylphorbol-13-acetate-induced signal transduction. J Biol Chem, 276, 46722-8.

234.      Bode, A.M., et al. (2001) Inhibition of epidermal growth factor-induced cell transformation and activator protein 1 activation by [6]-gingerol. Cancer Res, 61, 850-3.

235.      Ren, J., et al. (2000) Altered cardiac excitation-contraction coupling in ventricular myocytes from spontaneously diabetic BB rats. Am J Physiol Heart Circ Physiol, 279, H238-44.

236.      Nomura, M., et al. (2000) Inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced NF-kappaB activation by tea polyphenols, (-)-epigallocatechin gallate and theaflavins. Carcinogenesis, 21, 1885-90.

237.      Hamaty, M., et al. (2000) High glucose-enhanced acetylcholine stimulated CGMP masks impaired vascular reactivity in tail arteries from short-term hyperglycemic rats. Int J Exp Diabetes Res, 1, 69-79.

238.      Bode, A.M., et al. (2000) Signal transduction pathways: targets for chemoprevention of skin cancer. The Lancet Oncology, 1, 181-188.

239.      Bode, A.M., et al. (2000) Apoptosis induction by arsenic: mechanisms of actions and possible clinical applications for treating therapy-resistant cancers. Drug Resistance Updates, 3, 21-29.

240.      Vethanayagam, J.G., et al. (1999) Glutathione-dependent ascorbate recycling activity of rat serum albumin. Free Radic Biol Med, 26, 1591-8.

241.      Samson, W.K., et al. (1999) Antisense oligonucleotide treatment reveals a physiologically relevant role for adrenomedullin gene products in sodium intake. Brain Res, 818, 164-7.

242.      Brown-Borg, H.M., et al. (1999) Antioxidative mechanisms and plasma growth hormone levels: potential relationship in the aging process. Endocrine, 11, 41-8.

243.      Bode, A.M., et al. (1999) Analysis of water-soluble antioxidants by high-performance liquid chromatography with electrochemical detection. Methods Enzymol, 299, 77-83.

244.      Rose, R.C., et al. (1998) Ocular oxidants and antioxidant protection. Proc Soc Exp Biol Med, 217, 397-407.

245.      Meyer, T.E., et al. (1998) Changes in glutathione redox cycling and oxidative stress response in the malignant progression of NB2 lymphoma cells. Int J Cancer, 77, 55-63.

246.      Bartke, A., et al. (1998) Does growth hormone prevent or accelerate aging? Exp Gerontol, 33, 675-87.

247.      Bode, A.M. (1997) Metabolism of vitamin C in health and disease. In Sies, H. (ed.), Antioxidants in Disease-Mechanisms and Therapy. Academic Press, New York, vol. 38, pp. 21-47.

248.      Saari, J.T., et al. (1995) Defects of copper deficiency in rats are modified by dietary treatments that affect glycation. J Nutr, 125, 2925-34.

249.      Rose, R.C., et al. (1995) Analysis of water-soluble antioxidants by high-pressure liquid chromatography. Biochem J, 306, 101-5.

250.      Rose, R.C., et al. (1995) Comments on the glutathione-ascorbic acid redox couple. Free Radic Biol Med, 18, 955-6.

251.      Blake, M.J., et al. (1995) Blood pressure and heat shock protein expression in response to acute and chronic stress. Hypertension, 25, 539-44.

252.      Matz, J.M., et al. (1994) Dietary copper deficiency reduces heat shock protein expression in cardiovascular tissues. Faseb J, 8, 97-102.

253.      Foster, J.D., et al. (1994) Time-dependent inhibition of glucose 6-phosphatase by 3- mercaptopicolinic acid. Biochim Biophys Acta, 1208, 222-8.

254.      Bode, A.M., et al. (1994) Glycogenesis from glucose and ureagenesis in isolated perfused rat livers. Influence of ammonium ion, norvaline, and ethoxyzolamide. J Biol Chem, 269, 7879-86.

255.      Schell, D.A., et al. (1993) Measurement of ascorbic acid and dehydroascorbic acid in mammalian tissue utilizing HPLC and electrochemical detection. Biomed Chromatogr, 7, 267-72.

256.      Rose, R.C., et al. (1993) Biology of free radical scavengers: an evaluation of ascorbate. Faseb J, 7, 1135-42.

257.      Nordlie, R.C., et al. (1993) Recent advances in hepatic glucose 6-phosphatase regulation and function. Proc Soc Exp Biol Med, 203, 274-85.

258.      Bode, A.M., et al. (1993) Enzymatic basis for altered ascorbic acid and dehydroascorbic acid levels in diabetes. Biochem Biophys Res Commun, 191, 1347-53.

259.      Bode, A.M., et al. (1993) Reciprocal effects of proline and glutamine on glycogenesis from glucose and ureagenesis in isolated, perfused rat livers. J Biol Chem, 268, 16298-301.

260.      Bode, A.M., et al. (1993) Ascorbic acid regeneration by bovine iris-ciliary body. Curr Eye Res, 12, 593-601.

261.      Bode, A.M., et al. (1993) Inhibition of glucose-6-phosphate phosphohydrolase by 3- mercaptopicolinate and two analogs is metabolically directive. Biochem Cell Biol, 71, 113-21.

262.      Rose, R.C., et al. (1992) Short term effects of oxidized ascorbic acid on bovine corneal endothelium and human placenta. Life Sci, 50, 1543-9.

263.      Rose, R.C., et al. (1992) Tissue-mediated regeneration of ascorbic acid: is the process enzymatic? Enzyme, 46, 196-203.

264.      Bode, A.M., et al. (1992) Glyconeogenesis from L-proline involves metabolite inhibition of the glucose-6-phosphatase system. J Biol Chem, 267, 2860-3.

265.      Rose, R.C., et al. (1991) Ocular ascorbate transport and metabolism. Comp Biochem Physiol A, 100, 273-85.

266.      Bode, A.M., et al. (1991) Ascorbic acid uptake and metabolism by corneal endothelium. Invest Ophthalmol Vis Sci, 32, 2266-71.

267.      Bode, A.M., et al. (1990) Spontaneous decay of oxidized ascorbic acid (dehydro-L-ascorbic acid) evaluated by high-pressure liquid chromatography. Clin Chem, 36, 1807-9.

268.      Bode, A.M., et al. (1990) The relationship between plasma free fatty acids and liver mitochondrial function in vivo. Biochim Biophys Acta, 1047, 161-7.

269.      Byrd, S.K., et al. (1989) Effects of exercise of varying duration on sarcoplasmic reticulum function. J Appl Physiol, 66, 1383-9.

 

Personal interests and hobbies

New techno gadgets and MAC fanatic; would love to golf more in winter and summer; and next career goal is to be a computer animation engineer.