Anna Sundborger-Lunna - The Hormel Institute

Anna Sundborger-Lunna Ph.D
Assistant Professor
asundborger@hi.umn.edu

Cryo-EM and Molecular Cell Biology

Biography

2016-Present
Assistant Professor and Section Leader Cryo-EM and Molecular Cell Biology
The Hormel Institute/University of Minnesota
2010-2015
Postdoctoral Fellow
National Institute of Diabetes & Digestive & Kidney Diseases
2010
Ph.D. in Neuroscience
Karolinska Institute
2005
M.S. in Medical Biology
Linköping University
2001
B.S. in Medical Biology
Linköping University

Professional memberships

Biophysical Society
American Association for Cancer Research
Masonic Cancer Center

Research Interests

Cryo-EM and 3D reconstruction of protein complexes involved in intracellular membrane trafficking pathways.

Membrane remodeling in innate immunity and cancer.

The role of BAR proteins in autophagy and apoptosis.

Molecular mechanisms of anti- viral and anti-bacterial activities of membrane remodeling proteins.

Publications

Sundborger AC & Hinshaw JE. Dynamins and BAR proteins– gatekeepers in cancer. 2015. Critical Reviews on Oncogenesis: Oncogenic Biomarkers and Signal Transduction. Crit Rev Oncog. 20(5-6): 475-84.

Sambuughin N, Goldfarb LG, Sivtseva TM, Davydova TK, Vladimirtsev VA, Osakovskiy VL, Danilova AP, Nikitina RS, Ylakhova AN, Diachkovskaya MP, Sundborger AC, Renwick NM, Platonov FA, Hinshaw JE, Toro C. 2015. Adult-onset autosomal dominant spastic paraplegia linked to a GTPase-effector domain mutation of dynamin 2. BMC Neurology 15:223.

Mattila J-P*, Shnyrova AV*, Sundborger AC, Rodriguez Hortelano, Fuhrmans M, Neumann S, Müller M, Hinshaw JE, Schmid SL and Frolov A. Membrane fission occurs in two mechanistically distinct stages through a hemi-fission intermediate. 2015. Nature 524(7563):109-13.

Sundborger AC and Hinshaw JE. Regulating Dynamin Dynamics. 2014. F1000PrimeReports 6:85.

Sundborger AC, Fang S, Heymann JA, Ray P, Chappie JL and Hinshaw JE. 2011. A dynamin mutant defines a super-constricted prefission state. Cell Reports 8:3.

Sundborger AC, Soderblom C, Vorontsova O, Evergren E, Hinshaw JE and Shupliakov O. 2011. An endophilin-dynamin complex promotes budding of clathrin- coated vesicles during synaptic vesicle recycling. Journal of Cell Science. 124(1): 133-43.

Rao Y, Q, Rao*, Vahedi-Faridi A*, Sundborger AC, Pechstein A, Puchkov D, Shupliakov O, Saenger W and Haucke V. 2010. Molecular basis for SH3- domain-mediated regulation of F-BAR-mediated membrane deformation. Proceedings of the National Academy of Sciences 107(18).

Pechstein A, Bacetic J*, Vahede-Faridi A*, Gromova K*, Sundborger AC*, Tomilin N, Krainer G, Vorontsova O, Schaefer G, Owe S, Cousin M, Saenger W, Shupliakov O and Hauke V. 2010. Regulation of synaptic vesicles recycling by complex formation between intersectin 1 and the clathrin adaptor complex AP2. Proceedings of the National Academy of Sciences 107(9).

Evergren E*, Gad H*, Walther K*, Sundborger AC, Tomilin N and Shupliakov O. 2007. Intersectin is a negative regulator of dynamin recruitment to the synaptic endocytic zone in the central synapse. Journal of Neuroscience 27:2.

Tenger C, Sundborger AC, Jawien J and Zhou X. IL-18 accelerates Atherosclerosis accompanied by elevation of IFN-g and CXCL16 expression independently of T-cells. 2004. Arteriosclerosis & Thrombrobosis & Vascular Biology 25:791- 6.

Contact Information

Primary Research Areas

The goal of the Sundborger-Lunna lab is to unravel the molecular mechanisms controlling essential intracellular membrane remodeling and trafficking events, such as endo-lysosomal trafficking, apoptosis, autophagy and regulation of mitochondrial dynamics. Our main focus is to characterize structure and function of macromolecular protein complexes involved in the regulation of these pathways using Cryo-Electron Microscopy (Cryo-EM) in combination with biochemical assays and functional cell models. We are especially interested in how membrane bending BAR-domain proteins and members of the dynamin family of large GTPases, responsible for membrane fission and fusion, assemble into large complexes and coordinate their efforts to regulate fundamental cellular events. Long-term, we aim to investigate how dysregulation of intracellular membrane remodeling processes may contribute to infectious diseases and cancer.

Research Specialties

Cryo-electron microscopy
Biochemistry
Protein-lipid interactions

Awards

2014
NIH Fellows Award for Research Excellence, National
Institutes of Health
2007
Best Electron Microscopy Presentation, Chesapeake Society
for Microscopy