Ning Ling Kang -The Hormel Institute

Ningling Kang, Ph.D.
Associate Professor
nkang@hi.umn.edu

Tumor Microenvironment & Metastasis

Biography

Dr. Ningling Kang is the section leader of Tumor Microenvironment and Metastasis at the Hormel Institute. She received postdoctoral training in Department of Pediatric and Adolescent Medicine (2000-2003) and in Division of Gastroenterology and Hepatology, Department of internal Medicine (2003-2004) at Mayo Clinic, Rochester, Minnesota. Prior to joining the Hormel Institute, Dr. Kang has worked as an Associate Consultant in Research with academic appointment of Assistant Professor at Mayo Clinic from 2007 and 2013. Her research program, focusing on the prometastatic liver microenvironment and bidirectional interactions between cancer cells and the liver, is currently funded by NCI/NIH (2007-2021).

Education

BS
Beijing Normal University
Beijing, China – Biology
MS
Beijing Normal University Graduate School
Beijing, China – Genetics
Ph.D.
Free University Berlin
Berlin, Germany – Molecular Medicine
Post-doc
Mayo Clinic
Rochester, MN, USA – Cell biology and signaling

Awards

1996
Pre-doctoral fellowship in DFG Graduiertenkolleg GRK276 ‘Signalerkennung and– umsetzung’, Free University Berlin, Germany
1999
Ph.D. with Summa cum laude, Free University Berlin, Germany
2006
Sheila Sherlock Clinical and Translational Research in Liver Diseases Award, ALF/AASLD
2007
The Howard Temin Award, NCI/NIH
2008
Young Investigator Award, Mayo Clinic Angiogenesis Symposium
2009
Research Early Career Development Award, Mayo Clinic
2010
Pilot and Feasibility Award, P30 Mayo Clinic Center for Cell Signaling in GI, Mayo Clinic
2011
New Named Investigator, P30 Mayo Clinic Center for Cell Signaling in GI, Mayo Clinic

Professional memberships

P30 Mayo Clinic Center for Cell Signaling in Gastroenterology, Mayo Clinic
Masonic Cancer Center, University of Minnesota

Research Interests

Molecular Mechanisms of hepatic stellate cell activation
Stiffness-induced mechanosignaling in tumor-associated myofibroblasts

Publications

Dou C et al (2018) P300 Acetyltransferase Mediates Stiffness-Induced Activation of Hepatic Stellate Cells Into Tumor-promoting Myofibroblasts. Gastroenterology. 2018 Feb 15 (Epub ahead of print).

Xiang X et al (2018) Vasodilator-stimulated phosphoprotein promotes liver metastasis of gastrointestinal cancer by activating a β1-integrin-FAK-YAP1/TAZ signaling pathway. npj Precision Oncology 2018;2:2.

Kang N et al (2015) Membrane-to-Nucleus Signals and Epigenetic Mechanisms for Myofibroblastic Activation and Desmoplastic Stroma: Potential Therapeutic Targets for Liver Metastasis? Mol Cancer Res. 2015 Apr;13(4):604-12.

Liu C et al (2014) PDGF receptor alpha promotes TGF-β signaling in hepatic stellate cells via transcriptional and post transcriptional regulation of TGF-β receptors. Am J Physiol Gastrointest Liver Physiol. 2014 Oct1;307(7):G749-59.

Tu K et al (2015) VASP promotes TGF-β activation of hepatic stellate cells by regulating Rab11 dependent plasma membrane targeting of TGF-β receptors. Hepatology. 2015 Jan;61(1):361-74.

Liu C et al. (2013) IQGAP1 suppresses TβRII- mediated myofibroblastic activation and metastatic growth in liver. J Clin Invest. 2013 Mar 1;123(3):1138-56.

Kang N et al. Hepatic stellate cells: Partners in crime for liver metastases? Hepatology. 2011 Aug;54(2):707-13.

Routray C et al (2011) Protein kinase G signaling disrupts Rac1 dependent focal adhesion assembly in liver specific pericytes. Am J Physiol Cell Physiol 2011 Jul;301(1):C66-74.

Kang N et al (2010) Focal adhesion assembly in myofibroblasts fosters a microenvironment that promotes tumor growth. Am J Path 2010 Oct;177(4):1888-900.

Kang-Decker N et al (2008) Nitric oxide regulates tumor cell cross-talk with stromal cells in the tumor microenvironment of the liver. Am J Path 2008 Oct;173(4):1002-12.

Semela D et al (2008) PDGF signaling through ephrin-B2 regulates hepatic vascular structure and function. Gastroenterology. 2008 Aug;135(2):671-9.

Langer DA et al (2008) Nitric oxide promotes caspase-independent hepatic stellate cell apoptosis through the generation of reactive oxygen species. Hepatology 2008 May 5.
Kang-Decker N et al (2007) Nitric oxide promotes endothelial cell survival signaling through S-nitrosylation and activation of dynamin. J Cell Sci 2007 Feb 1;120(Pt 3):492-501.

Wendt MK et al (2006) Silencing of epithelial CXCL12 expression by DNA hypermethylation promotes colonic carcinoma metastasis. Oncogene, 2006 Aug 17;25(36):4986-97.

Bhattacharya R et al (2005) Regulatory role of dynamin-2 in VEGFR-2/KDR-mediated endothelial signaling. FASEB J 2005 Oct;19(12):1692-4.

Kang-Decker N et al (2004) Loss of CBP causes T cell lymphomagenesis in synergy with p27Kip1 insufficiency. Cancer Cell 2004 Feb;5(2):177-89.

Babu JR et al (2003) Rae1 is an essential mitotic checkpoint regulator that cooperates with Bub3 to prevent chromosome missegregation. J Cell Biol 2003 Feb 3; 160(3):341-53.

Kang-Decker, N et al (2001) Lack of acrosome formation in Hrb-deficient mice. Science 2001 Nov 16; 294(5546):1531-3.

Contact Information

Primary Research Areas

Prometastatic tumor microenvironment of the liver and paracrine interactions between cancer cells and hepatic stellate cells

Research Specialties