Dr. Zigang Dong
Professor, Cellular and Molecular Biology
DrPH Columbia University
M.D. Henan Medical University, China
zgdong@hi.umn.edu
507-437-9600
Dr. Zigang Dong DrPH Columbia University zgdong@hi.umn.edu
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Research Interests
The major focus in the Cellular and Molecular Biology section is the molecular mechanisms of cancer development and the actions of chemopreventive agents in cancer prevention. The tumor promotion stage is a rate-limiting step in cancer development (carcinogenesis) and therefore understanding the molecular mechanisms in this step is important for progress toward cancer prevention.
We address response of mammalian cells to tumor promoters at the level of transcription factors and protein kinases. Our research examines the tumor promoter-induced signal transduction pathways and their role in the process of neoplastic cell transformation, carcinogenesis, and cancer prevention with the following:
Another main emphasis of our lab is the elucidation of mechanism(s) of the anticancer actions attributed to several chemopreventive compounds. These are compounds considered to have little or no toxicity and are present in commonly consumed foods and beverages.
Publications
Choi HS, Kang BS, Shim JH, Cho YY, Choi BY, Bode AM, Dong Z. Cot, a novel kinase of histone H3, induces cellular transformation through up-regulation of c-fos transcriptional activity. FASEB J. (2008) Jan;22(1):113-26.
He Z, Tang F, Ermakova S, Li M, Zhao Q, Cho YY, Ma WY, Choi HS, Bode AM, Yang CS, Dong Z. Fyn is a novel target of (-)-epigallocatechin gallate in the inhibition of JB6 Cl41 cell transformation. Mol Carcinog. (2007) Dec 19; [Epub ahead of print].
Malakhova M, Tereshko V, Lee SY, Yao K, Cho YY, Bode A, Dong Z. Structural basis for activation of the autoinhibitory C-terminal kinase domain of p90 RSK2. Nat Struct Mol Biol. (2007) Dec 16; [Epub ahead of print].
Yao K, Cho YY, Bergen HR 3rd, Madden BJ, Choi BY, Ma WY, Bode AM, Dong Z. Nuclear factor of activated T3 is a negative regulator of Ras-JNK1/2-AP-1 induced cell transformation. Cancer Res. (2007) Sep 15;67(18):8725-35.
Cho YY, Yao K, Kim HG, Kang BS, Zheng D, Bode AM, Dong Z. Ribosomal S6 kinase 2 is a key regulator in tumor promoter induced cell transformation. Cancer Res. (2007) Sep 1;67(17):8104-12.
Kang NJ, Lee KW, Rogozin EA, Cho YY, Heo YS, Bode AM, Lee HJ, Dong Z. Equol, a metabolite of the soybean isoflavone daidzein, inhibits neoplastic cell transformation by targeting the MEK/ERK/p90RSK/activator protein-1 pathway. J Biol Chem. (2007) Nov 9;282(45):32856-66.
Lee KW, Kang NJ, Rogozin EA, Kim HG, Cho YY, Bode AM, Lee HJ, Surh YJ, Bowden GT, Dong Z. Myricetin is a novel natural inhibitor of neoplastic cell transformation and MEK1. Carcinogenesis (2007) Sep;28(9):1918-27.
Zhu F, Zykova TA, Kang BS, Wang Z, Ebeling MC, Abe Y, Ma WY, Bode AM, Dong Z. Bidirectional signals transduced by TOPK-ERK interaction increase tumorigenesis of HCT116 colorectal cancer cells. Gastroenterology (2007) Jul;133(1):219-31.
Fedorov SN, Shubina LK, Bode AM, Stonik VA, Dong Z. Dactylone inhibits epidermal growth factor-induced transformation and phenotype expression of human cancer cells and induces G1-S arrest and apoptosis. Cancer Res. (2007) Jun 15;67(12):5914-20.
Oh SM, Zhu F, Cho YY, Lee KW, Kang BS, Kim HG, Zykova T, Bode AM, Dong Z. T-lymphokine-activated killer cell-originated protein kinase functions as a positive regulator of c-Jun-NH2-kinase 1 signaling and H-Ras-induced cell transformation. Cancer Res. (2007) Jun 1;67(11):5186-94.
Bode AM, Dong Z. The functional contrariety of JNK. Mol Carcinog. (2007) Aug;46(8):591-8. Review.
Zykova TA, Zhu F, Zhang Y, Bode AM, Dong Z. Involvement of ERKs, RSK2 and PKR in UVA-induced signal transduction toward phosphorylation of eIF2alpha (Ser(51)). Carcinogenesis (2007) Jul;28(7):1543-51.
Li M, He Z, Ermakova S, Zheng D, Tang F, Cho YY, Zhu F, Ma WY, Sham Y, Rogozin EA, Bode AM, Cao Y, Dong Z. Direct inhibition of insulin-like growth factor-I receptor kinase activity by (-)-epigallocatechin-3-gallate regulates cell transformation. Cancer Epidemiol Biomarkers Prev. (2007) Mar;16(3):598-605.
Song L, Li J, Ye J, Yu G, Ding J, Zhang D, Ouyang W, Dong Z, Kim SO, Huang C. p85alpha acts as a novel signal transducer for mediation of cellular apoptotic response to UV radiation. Mol Cell Biol. (2007) Apr;27(7):2713-31.
Cho YY, Yao K, Bode AM, Bergen HR 3rd, Madden BJ, Oh SM, Ermakova S, Kang BS, Choi HS, Shim JH, Dong Z. RSK2 mediates muscle cell differentiation through regulation of NFAT3. J Biol Chem. (2007) Mar 16;282(11):8380-92.
Yan G, Luo W, Lu Z, Luo X, Li L, Liu S, Liu Y, Tang M, Dong Z, Cao Y. Epstein-Barr virus latent membrane protein 1 mediates phosphorylation and nuclear translocation of annexin A2 by activating PKC pathway. Cell Signal. (2007) Feb;19(2):341-8.
PubMed (a service of the National Library of Medicine) provides a comprehensive list of Dr. Dong's recent publications.
Current Funding
National Institutes of Health
Chemoprevention of Skin Cancer Program Project
(U of Arizona)
Anticarcinogenic Mechanisms of Tea Constituents
Study on Ultraviolet-induced Signal Transduction
Molecular Basis of Arsenic-induced Cell Transformation
Mechanisms of Chemopreventive Effect of Resveratrol
Inhibition of Carcinogenesis by Tea and Tea Constituents
Minnesota Partnership for BioTechnology & Medical Genomics
Selective, Small-molecule Inhibitors of JNK2 as Anti-cancer Drugs
Cellular and Molecular Biology Researchers
Front Row: Duo Zheng, Tatyana Zykova, Evgeny Rogozin, Svetlana Ermakova, Ke Yao, Nam Joo Kang
Middle Row: Mara Ebeling, Feng Zhu, Ann Bode, Zigang Dong, Wei-Ya Ma, Ming Li, Jung-Hyun Shim
Back Row: Faqing Tang, Hong-Gyum Kim, Bong Seok Kang, Yong Yeon Cho, Hong-Seok Choi, Sang-Muk Oh