Project Description

Ann Bode Ph.D. - The Hormel Institute


Ann Bode, Ph.D.

Former Interim ED
Cellular & Molecular Biology


Ann M. Bode is the Associate Director of The Hormel Institute and  co-leader of Molecular and Cellular Biology research sections at The Hormel Institute. Dr. Bode received her B.S. and M.S. from Southern Illinois University and her Ph.D. from the University of Oregon. She did her post-doctoral work in the Department of Biochemistry in the School of Medicine at the University of North Dakota. She was a full-time tenured faculty member in the Department of Physiology in the School of Medicine where she was Director of Graduate Studies, Head of Cardiovascular Physiology for First Year Medical Students, and ran a research program specializing in the role of reactive oxygen species and antioxidants in chronic diseases, including cancer and diabetes.  Prior to receiving her Ph.D., Dr. Bode spent many years as a college women’s athletic director and volleyball coach.


Southern Illinois University, Carbondale, Illinois
Physical Education
Southern Illinois University, Carbondale, Illinois
University of Oregon, Eugene, Oregon
Applied Physiology with Anatomy and Biochemistry as second areas of study
University of North Dakota, Grand Forks, ND

Personal interests and hobbies

New techno gadgets and MAC fanatic; would love to golf more in winter and summer; and next career goal is to be a computer animation engineer.

Professional memberships

American Association for Cancer Research-University of Minnesota Cancer Center

-Ad hoc NIH study section participant SBIR, DMP, CDP, Minority Fellowship Training 2005-current

-Member-Special Emphasis Panel-NIH PREVENT Program

-Reviewer for L’Oreal USA Fellowships For Women in Science 2008-current

Research Interests

-Molecular mechanisms of carcinogenesis and chemoprevention of cancer-Signal transduction pathways (MAP kinases, S6 kinases) and transcription factors (AP-1, NF-kB, NFAT, p53) in development, and disease-Molecular mechanisms of chemopreventive effect of natural dietary compounds especially [6]-gingerol, tea polyphenols and resveratrol

-Targeting transcription factors for cancer prevention and treatment

-Oxidative stress, ultraviolet, arsenic and other environmental human carcinogen-induced signal transduction pathways and carcinogenesis

-Cancer biomarkers and drug resistance.


1.         Bode, A.M., et al. (2015) Toxic Phytochemicals and Their Potential Risks for Human Cancer. Cancer Prev Res (Phila), 8, 1-8.

2.         Yu, X., et al. (2014) Neoalbaconol induces cell death through necroptosis by regulating RIPK-dependent autocrine TNFalpha and ROS production. Oncotarget.

3.         Yao, K., et al. (2014) JNK1 and 2 play a negative role in reprogramming to pluripotent stem cells by suppressing Klf4 activity. Stem Cell Res, 12, 139-52.

4.         Yao, K., et al. (2014) Kaempferol targets RSK2 and MSK1 to suppress UV radiation-induced skin cancer. Cancer Prev Res (Phila), 7, 958-67.

5.         Yao, K., et al. (2014) Licochalcone A, a natural inhibitor of c-Jun N-terminal kinase 1. Cancer prevention research, 7, 139-49.

6.         Yang, G., et al. (2014) Caffeic acid directly targets ERK1/2 to attenuate solar UV-induced skin carcinogenesis. Cancer Prev Res (Phila), 7, 1056-66.

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7.         Xiao, L., et al. (2014) Targeting Epstein-Barr virus oncoprotein LMP1-mediated glycolysis sensitizes nasopharyngeal carcinoma to radiation therapy. Oncogene, 33, 4568-78.

8.         Wu, Y., et al. (2014) A combination of paclitaxel and siRNA-mediated silencing of Stathmin inhibits growth and promotes apoptosis of nasopharyngeal carcinoma cells. Cellular oncology, 37, 53-67.

9.         Wen, W., et al. (2014) Knockdown of RNF2 induces apoptosis by regulating MDM2 and p53 stability. Oncogene, 33, 421-8.

10.        Shin, D.J., et al. (2014) 20-O-beta-D-glucopyranosyl-20(S)-protopanaxadiol suppresses UV-Induced MMP-1 expression through AMPK-mediated mTOR inhibition as a downstream of the PKA-LKB1 pathway. J Cell Biochem, 115, 1702-11.

11.        Sheng, Y., et al. (2014) 3,6,2′,4′,5′-Pentahydroxyflavone, an orally bioavailable multiple protein kinase inhibitor, overcomes gefitinib resistance in non-small cell lung cancer. J Biol Chem, 289, 28192-201.

12.        Oi, N., et al. (2014) Resveratrol induces apoptosis by directly targeting Ras-GTPase-activating protein SH3 domain-binding protein 1. Oncogene.

13.        Nicastro, H.L., et al. (2014) Preventive effects of NSAIDs, NO-NSAIDs, and NSAIDs plus difluoromethylornithine in a chemically induced urinary bladder cancer model. Cancer Prev Res (Phila), 7, 246-54.

14.        Liu, K., et al. (2014) Eupafolin suppresses prostate cancer by targeting phosphatidylinositol 3-kinase-mediated Akt signaling. Mol Carcinog.

15.        Liu, H., et al. (2014) A derivative of chrysin suppresses two-stage skin carcinogenesis by inhibiting mitogen- and stress-activated kinase 1. Cancer Prev Res (Phila), 7, 74-85.

16.        Lim, T.G., et al. (2014) Curcumin suppresses proliferation of colon cancer cells by targeting CDK2. Cancer Prev Res (Phila), 7, 466-74.

17.        Lim, T.G., et al. (2014) The daidzein metabolite, 6,7,4′-Trihydroxyisoflavone, is a novel inhibitor of PKCalpha in suppressing solar UV-induced matrix metalloproteinase 1. Int J Mol Sci, 15, 21419-32.

18.        Lim do, Y., et al. (2014) (+)-2-(1-Hydroxyl-4-oxocyclohexyl) ethyl caffeate suppresses solar UV-induced skin carcinogenesis by targeting PI3K, ERK1/2, and p38. Cancer Prev Res (Phila), 7, 856-65.

19.        Li, H., et al. (2014) 6-C-(E-phenylethenyl)-naringenin suppresses colorectal cancer growth by inhibiting cyclooxygenase-1. Cancer Res, 74, 243-52.

20.        Kim, S.H., et al. (2014) ERK1 phosphorylates Nanog to regulate protein stability and stem cell self-renewal. Stem cell research, 13, 1-11.

21.        Kim, M.S., et al. (2014) Src is a novel potential off-target of RXR agonists, 9-cis-UAB30 and Targretin, in human breast cancer cells. Mol Carcinog.

22.        Kim, M.S., et al. (2014) Naproxen induces cell-cycle arrest and apoptosis in human urinary bladder cancer cell lines and chemically induced cancers by targeting PI3K. Cancer Prev Res (Phila), 7, 236-45.

23.        Kim, M.O., et al. (2014) [6]-shogaol inhibits growth and induces apoptosis of non-small cell lung cancer cells by directly regulating Akt1/2. Carcinogenesis, 35, 683-91.

24.        Kang, S., et al. (2014) The ginsenoside 20-O-beta-D-glucopyranosyl-20(S)-protopanaxadiol induces autophagy and apoptosis in human melanoma via AMPK/JNK phosphorylation. PLoS One, 9, e104305.

25.        Kang, S., et al. (2014) Hirsutenone in Alnus extract inhibits akt activity and suppresses prostate cancer cell proliferation. Mol Carcinog.

26.        Jung, S.K., et al. (2014) Butein, a novel dual inhibitor of MET and EGFR, overcomes gefitinib-resistant lung cancer growth. Mol Carcinog.

27.        Jung, S.K., et al. (2014) Isoliquiritigenin Induces Apoptosis and Inhibits Xenograft Tumor Growth of Human Lung Cancer Cells by Targeting Both Wild Type and L858R/T790M Mutant EGFR. J Biol Chem, 289, 35839-48.

28.        Jung, S.K., et al. (2014) The P110 subunit of PI3-K is a therapeutic target of acacetin in skin cancer. Carcinogenesis, 35, 123-30.

29.        Hu, Z.Y., et al. (2014) Glycolytic genes in cancer cells are more than glucose metabolic regulators. J Mol Med (Berl), 92, 837-45.

30.        Fu, Y., et al. (2014) Antioxidants decrease the apoptotic effect of 5-Fu in colon cancer by regulating Src-dependent caspase-7 phosphorylation. Cell Death Dis, 5, e983.

31.        Duan, Z., et al. (2014) Activation of the Ig Ialpha1 promoter by the transcription factor Ets-1 triggers Ig Ialpha1-Calpha1 germline transcription in epithelial cancer cells. Cell Mol Immunol, 11, 197-205.

32.        De Luca, A., et al. (2014) Src and CXCR4 are involved in the invasiveness of breast cancer cells with acquired resistance to lapatinib. Cell Cycle, 13, 148-56.

33.        Yu, X., et al. (2013) The role of necroptosis, an alternative form of cell death, in cancer therapy. Expert review of anticancer therapy, 13, 883-93.

34.        Xu, J., et al. (2013) Tyrosylprotein sulfotransferase-1 and tyrosine sulfation of chemokine receptor 4 are induced by epstein-barr virus encoded latent membrane protein 1 and associated with the metastatic potential of human nasopharyngeal carcinoma. PloS one, 8, e56114.

35.        Xie, H., et al. (2013) Identification of an Aurora kinase inhibitor specific for the Aurora B isoform. Cancer research, 73, 716-24.

36.        Xie, H., et al. (2013) Discovery of the novel mTOR inhibitor and its antitumor activities in vitro and in vivo. Molecular cancer therapeutics, 12, 950-8.

37.        Song, N.R., et al. (2013) Isoangustone A, A Novel Licorice Compound, Inhibits Cell Proliferation by Targeting PI3K, MKK4, and MKK7 in Human Melanoma. Cancer prevention research, 6, 1293-303.

38.        Lubet, R.A., et al. (2013) Effect of intermittent dosing regimens of erlotinib on methylnitrosourea-induced mammary carcinogenesis. Cancer prevention research, 6, 448-54.

39.        Lu, Y., et al. (2013) Concordant effects of aromatase inhibitors on gene expression in ER+ Rat and human mammary cancers and modulation of the proteins coded by these genes. Cancer prevention research, 6, 1151-61.

40.        Liu, X., et al. (2013) Regulation of microRNAs by epigenetics and their interplay involved in cancer. Journal of experimental & clinical cancer research : CR, 32, 96.

41.        Liu, S., et al. (2013) (-)-Epigallocatechin-3-gallate inhibition of Epstein-Barr virus spontaneous lytic infection involves ERK1/2 and PI3-K/Akt signaling in EBV-positive cells. Carcinogenesis, 34, 627-37.

42.        Liu, K., et al. (2013) Sunlight UV-induced skin cancer relies upon activation of the p38alpha signaling pathway. Cancer research, 73, 2181-8.

43.        Liu, H., et al. (2013) A Chrysin Derivative Suppresses Skin Cancer Growth by Inhibiting Cyclin-dependent Kinases. The Journal of biological chemistry, 288, 25924-37.

44.        Lim, T.G., et al. (2013) MLK3 is a direct target of biochanin A, which plays a role in solar UV-induced COX-2 expression in human keratinocytes. Biochemical pharmacology, 86, 896-903.

45.        Li, W., et al. (2013) TRAF4 Is a Critical Molecule for Akt Activation in Lung Cancer. Cancer research, 73, 6938-50.

46.        Li, J., et al. (2013) Quercetin-3-methyl ether inhibits lapatinib-sensitive and -resistant breast cancer cell growth by inducing G(2)/M arrest and apoptosis. Molecular carcinogenesis, 52, 134-43.

47.        Li, H., et al. (2013) Select dietary phytochemicals function as inhibitors of COX-1 but not COX-2. PloS one, 8, e76452.

48.        Lee, S.Y., et al. (2013) Esculetin Suppresses Proliferation of Human Colon Cancer Cells by Directly Targeting beta-Catenin. Cancer prevention research, 6, 1356-64.

49.        Lee, M.H., et al. (2013) Direct targeting of MEK1/2 and RSK2 by silybin induces cell-cycle arrest and inhibits melanoma cell growth. Cancer prevention research, 6, 455-65.

50.        Lee, M.H., et al. (2013) Tumor suppressor p16(INK4a) inhibits cancer cell growth by downregulating eEF1A2 through a direct interaction. Journal of cell science, 126, 1744-52.

51.        Kim, D.J., et al. (2013) CInQ-03, a novel allosteric MEK inhibitor, suppresses cancer growth in vitro and in vivo. Carcinogenesis, 34, 1134-43.

52.        Keum, Y.S., et al. (2013) UVB-induced COX-2 expression requires histone H3 phosphorylation at Ser10 and Ser28. Oncogene, 32, 444-52.

53.        Hwang, J.A., et al. (2013) 20-O-beta-d-glucopyranosyl-20(S)-protopanaxadiol, a metabolite of ginseng, inhibits colon cancer growth by targeting TRPC channel-mediated calcium influx. The Journal of nutritional biochemistry, 24, 1096-104.

54.        Deng, Q., et al. (2013) Neoalbaconol induces energy depletion and multiple cell death in cancer cells by targeting PDK1-PI3-K/Akt signaling pathway. Cell death & disease, 4, e804.

55.        Cho, Y.Y., et al. (2013) Autophagy and cellular senescence mediated by sox2 suppress malignancy of cancer cells. PloS one, 8, e57172.

56.        Byun, S., et al. (2013) USP8 Is a Novel Target for Overcoming Gefitinib Resistance in Lung Cancer. Clinical cancer research : an official journal of the American Association for Cancer Research, 19, 3894-3904.

57.        Bode, A.M., et al. (2013) Signal transduction and molecular targets of selected flavonoids. Antioxidants & redox signaling, 19, 163-80.

58.        Baek, S., et al. (2013) Structural and functional analysis of the natural JNK1 inhibitor quercetagetin. Journal of molecular biology, 425, 411-23.

59.        Zhao, L., et al. (2012) Regulatory mechanisms and clinical perspectives of miRNA in tumor radiosensitivity. Carcinogenesis, 33, 2220-7.

60.        Zhang, J., et al. (2012) Rack1 protects N-terminal phosphorylated c-Jun from Fbw7-mediated degradation. Oncogene, 31, 1835-44.

61.        Xie, H., et al. (2012) Identification of mammalian target of rapamycin as a direct target of fenretinide both in vitro and in vivo. Carcinogenesis, 33, 1814-21.

62.        Peng, C., et al. (2012) Tumor necrosis factor receptor-associated factor family protein 2 is a key mediator of the epidermal growth factor-induced ribosomal S6 kinase 2/cAMP-responsive element-binding protein/Fos protein signaling pathway. The Journal of biological chemistry, 287, 25881-92.

63.        Oi, N., et al. (2012) Taxifolin Suppresses UV-Induced Skin Carcinogenesis by Targeting EGFR and PI3K. Cancer prevention research, 5, 1103-14.

64.        Liu, K., et al. (2012) Aloe-emodin suppresses prostate cancer by targeting the mTOR complex 2. Carcinogenesis, 33, 1406-11.

65.        Liu, H., et al. (2012) EBV-encoded LMP1 upregulates Igkappa 3’enhancer activity and Igkappa expression in nasopharyngeal cancer cells by activating the Ets-1 through ERKs signaling. PloS one, 7, e32624.

66.        Li, Z., et al. (2012) EBV encoded miR-BHRF1-1 potentiates viral lytic replication by downregulating host p53 in nasopharyngeal carcinoma. The international journal of biochemistry & cell biology, 44, 275-9.

67.        Li, X., et al. (2012) Ceftriaxone, an FDA-approved cephalosporin antibiotic, suppresses lung cancer growth by targeting Aurora B. Carcinogenesis, 33, 2548-57.

68.        Li, M., et al. (2012) Promotion of cell proliferation and inhibition of ADCC by cancerous immunoglobulin expressed in cancer cell lines. Cellular & molecular immunology, 9, 54-61.

69.        Li, J., et al. (2012) Quercetin-3-methyl ether suppresses proliferation of mouse epidermal JB6 P+ cells by targeting ERKs. Carcinogenesis, 33, 459-65.

70.        Li, J., et al. (2012) Norathyriol suppresses skin cancers induced by solar ultraviolet radiation by targeting ERK kinases. Cancer research, 72, 260-70.

71.        Lee, S.Y., et al. (2012) The Role of Heterodimeric AP-1 Protein Comprised of JunD and c-Fos Proteins in Hematopoiesis. The Journal of biological chemistry, 287, 31342-8.

72.        Kim, M.O., et al. (2012) ERK1 and ERK2 regulate embryonic stem cell self-renewal through phosphorylation of Klf4. Nature structural & molecular biology, 19, 283-90.

73.        Kim, H.G., et al. (2012) Polycomb (PcG) Proteins, BMI1 and SUZ12, Regulate Arsenic-induced Cell Transformation. The Journal of biological chemistry, 287, 31920-8.

74.        Kim, D.J., et al. (2012) Novel TOPK inhibitor HI-TOPK-032 effectively suppresses colon cancer growth. Cancer research, 72, 3060-8.

75.        He, Z., et al. (2012) Analysis of the role of p38 MAP kinase in epidermal growth factor-induced JB6 Cl41 cell transformation by cDNA array. Gene, 497, 71-8.

76.        Guo, L., et al. (2012) Epstein-Barr virus oncoprotein LMP1 mediates survivin upregulation by p53 contributing to G1/S cell cycle progression in nasopharyngeal carcinoma. International journal of molecular medicine, 29, 574-80.

77.        Cho, Y.Y., et al. (2012) RSK2 as a key regulator in human skin cancer. Carcinogenesis, 33, 2529-37.

78.        Chen, H., et al. (2012) Prediction of molecular targets of cancer preventing flavonoid compounds using computational methods. PloS one, 7, e38261.

79.        Bode, A.M., et al. (2012) Effects of Dietary Effectors on Signal Transduction Pathways Related to Cancer Prevention. In Bidlack, W.R., et al. (eds.), Nutritional Genomics–The Impact of Dietary Regulation of Gene Function on Human Disease. CRC Press, New York, pp. 243-268.

80.        Zhu, F., et al. (2011) Phosphorylation of H2AX at Ser139 and a new phosphorylation site Ser16 by RSK2 decreases H2AX ubiquitination and inhibits cell transformation. Cancer Res, 71, 393-403.

81.        Urusova, D.V., et al. (2011) Epigallocatechin-gallate suppresses tumorigenesis by directly targeting Pin1. Cancer prevention research, 4, 1366-77.

82.        Rouzer, C.A., et al. (2011) Green tea gets molecular. Cancer prevention research, 4, 1343-5.

83.        Peng, C., et al. (2011) Phosphorylation of caspase-8 (Thr-263) by ribosomal S6 kinase 2 (RSK2) mediates caspase-8 ubiquitination and stability. J Biol Chem, 286, 6946-54.

84.        Luo, X.J., et al. (2011) DAPK1 mediates the G1 phase arrest in human nasopharyngeal carcinoma cells induced by grifolin, a potential antitumor natural product. European journal of pharmacology, 670, 427-34.

85.        Lubet, R.A., et al. (2011) Efficacy of the EGFr inhibitor Iressa on development of chemically-induced urinary bladder cancers: Dose dependency and modulation of biomarkers. Oncol Rep, 25, 1389-97.

86.        Liu, K., et al. (2011) Eriodictyol inhibits RSK2-ATF1 signaling and suppresses EGF-induced neoplastic cell transformation. J Biol Chem, 286, 2057-66.

87.        Li, Y., et al. (2011) Discovery of novel checkpoint kinase 1 inhibitors by virtual screening based on multiple crystal structures. Journal of chemical information and modeling, 51, 2904-14.

88.        Li, X., et al. (2011) Phosphorylation of Caspase-7 by p21-activated Protein Kinase (PAK) 2 Inhibits Chemotherapeutic Drug-induced Apoptosis of Breast Cancer Cell Lines. J Biol Chem, 286, 22291-9.

89.        Li, T., et al. (2011) P21-activated protein kinase (PAK2)-mediated c-Jun phosphorylation at 5 threonine sites promotes cell transformation. Carcinogenesis, 32, 659-66.

90.        Li, S., et al. (2011) T-LAK cell-originated protein kinase (TOPK) phosphorylation of MKP1 protein prevents solar ultraviolet light-induced inflammation through inhibition of the p38 protein signaling pathway. The Journal of biological chemistry, 286, 29601-9.

91.        Li, S., et al. (2011) TRPV1-antagonist AMG9810 promotes mouse skin tumorigenesis through EGFR/Akt signaling. Carcinogenesis, 32, 779-85.

92.        Li, J., et al. (2011) Lapatinib, a Preventive/Therapeutic Agent against Mammary Cancer, Suppresses RTK-Mediated Signaling through Multiple Signaling Pathways. Cancer Prev Res (Phila), 4, 1190-7.

93.        Lee, K.W., et al. (2011) Molecular targets of phytochemicals for cancer prevention. Nat Rev Cancer, 11, 211-8.

94.        Lee, D.E., et al. (2011) 6,7,4′-trihydroxyisoflavone inhibits HCT-116 human colon cancer cell proliferation by targeting CDK1 and CDK2. Carcinogenesis, 32, 629-35.

95.        Lee, D.E., et al. (2011) 7,3′,4′-Trihydroxyisoflavone, a metabolite of the soy isoflavone daidzein, suppresses ultraviolet B-induced skin cancer by targeting Cot and MKK4. J Biol Chem, 286, 14246-56.

96.        Lau, A.T., et al. (2011) Phosphorylation of Histone H2B Serine 32 Is Linked to Cell Transformation. J Biol Chem, 286, 26628-37.

97.        Kim, M.O., et al. (2011) Embryonic stem-cell-preconditioned microenvironment induces loss of cancer cell properties in human melanoma cells. Pigment cell & melanoma research, 24, 922-31.

98.        Kim, J.E., et al. (2011) Isorhamnetin Suppresses Skin Cancer through Direct Inhibition of MEK1 and PI3-K. Cancer Prev Res (Phila), 4, 582-91.

99.        Kim, D.J., et al. (2011) (3-Chloroacetyl)-indole, a Novel Allosteric AKT Inhibitor, Suppresses Colon Cancer Growth In Vitro and In Vivo. Cancer prevention research, 4, 1842-51.

100.      Kang, N.J., et al. (2011) Coffee phenolic phytochemicals suppress colon cancer metastasis by targeting MEK and TOPK. Carcinogenesis, 32, 921-8.

101.      Hu, D., et al. (2011) Heterogeneity of aberrant immunoglobulin expression in cancer cells. Cellular & molecular immunology, 8, 479-85.

102.      Hoenerhoff, M.J., et al. (2011) Pathologic progression of mammary carcinomas in a C3(1)/SV40 T/t-antigen transgenic rat model of human triple-negative and Her2-positive breast cancer. Transgenic Res, 20, 247-59.

103.      Bode, A.M., et al. (2011) The Amazing and Mighty Ginger. In Benzie, I.F.F., et al. (eds.), Herbal Medicine–Biomolecular and Clinical Aspects. CRC Press–Taylor and Francis Group, New York, pp. 131-156.

104.      Bode, A.M., et al. (2011) The two faces of capsaicin. Cancer Res, 71, 2809-14.

105.      Zykova, T.A., et al. (2010) T-LAK cell-originated protein kinase (TOPK) phosphorylation of Prx1 at Ser-32 prevents UVB-induced apoptosis in RPMI7951 melanoma cells through the regulation of Prx1 peroxidase activity. J Biol Chem, 285, 29138-46.

106.      Xu, Y.M., et al. (2010) Extracellular signal-regulated kinase 8-mediated c-Jun phosphorylation increases tumorigenesis of human colon cancer. Cancer Res, 70, 3218-27.

107.      Wen, W., et al. (2010) MST1 promotes apoptosis through phosphorylation of histone H2AX. J Biol Chem, 285, 39108-16.

108.      Surh, Y.J., et al. (2010) Breaking the NF-{kappa}B and STAT3 alliance inhibits inflammation and pancreatic tumorigenesis. Cancer Prev Res (Phila), 3, 1379-81.

109.      Shim, J.H., et al. (2010) Epigallocatechin gallate suppresses lung cancer cell growth through Ras-GTPase-activating protein SH3 domain-binding protein 1. Cancer Prev Res (Phila), 3, 670-9.

110.      Peng, C., et al. (2010) RSK2 mediates NF-{kappa}B activity through the phosphorylation of IkappaBalpha in the TNF-R1 pathway. FASEB J, 24, 3490-9.

111.      Oi, N., et al. (2010) Resveratrol, a red wine polyphenol, suppresses pancreatic cancer by inhibiting leukotriene a4 hydrolase. Cancer Res, 70, 9755-64.

112.      Malakhova, M., et al. (2010) The crystal structure of the active form of the C-terminal kinase domain of mitogen- and stress-activated protein kinase 1. J Mol Biol, 399, 41-52.

113.      Lee, S.Y., et al. (2010) Histone XH2AX is required for Xenopus anterior neural development: critical role of threonine 16 phosphorylation. J Biol Chem, 285, 29525-34.

114.      Lee, K.M., et al. (2010) Kaempferol inhibits UVB-induced COX-2 expression by suppressing Src kinase activity. Biochem Pharmacol, 80, 2042-9.

115.      Lee, K.M., et al. (2010) 5-deoxykaempferol plays a potential therapeutic role by targeting multiple signaling pathways in skin cancer. Cancer Prev Res (Phila Pa), 3, 454-65.

116.      Lee, D.E., et al. (2010) 7,3′,4′-Trihydroxyisoflavone inhibits epidermal growth factor-induced proliferation and transformation of JB6 P+ mouse epidermal cells by suppressing cyclin-dependent kinases and phosphatidylinositol 3-kinase. J Biol Chem, 285, 21458-66.

117.      Jung, S.K., et al. (2010) Myricetin suppresses UVB-induced wrinkle formation and MMP-9 expression by inhibiting Raf. Biochem Pharmacol, 79, 1455-61.

118.      Jung, S.K., et al. (2010) Myricetin inhibits UVB-induced angiogenesis by regulating PI-3 kinase in vivo. Carcinogenesis, 31, 911-7.

119.      Jeong, C.H., et al. (2010) Phosphorylation of sox2 cooperates in reprogramming to pluripotent stem cells. Stem Cells, 28, 2141-50.

120.      Jeon, Y.J., et al. (2010) Role of NEK6 in tumor promoter-induced transformation in JB6 C141 mouse skin epidermal cells. J Biol Chem, 285, 28126-33.

121.      Hwang, M.K., et al. (2010) Cocarcinogenic effect of capsaicin involves activation of EGFR signaling but not TRPV1. Cancer Res, 70, 6859-69.

122.      Fritz, V., et al. (2010) Glucosinolate Enhancement in Cabbage Induced by Jasmonic Acid Application. HortScience, 45, 1188-1191.

123.      Fedorov, S., et al. (2010) The anticancer effects of actinoporin RTX-A from the sea anemone Heteractis crispa (=Radianthus macrodactylus). Toxicon, 55, 811-7.

124.      Byun, S., et al. (2010) Luteolin inhibits protein kinase C(epsilon) and c-Src activities and UVB-induced skin cancer. Cancer Res, 70, 2415-23.

125.      Bode, A.M., et al. (2010) Update on cancer prevention research in the United States and china: the 2009 china–u.s. Forum on frontiers of cancer research. Cancer Prev Res (Phila), 3, 1630-7.

126.      Yao, K., et al. (2009) A selective small-molecule inhibitor of c-Jun N-terminal kinase 1. FEBS Lett, 583, 2208-12.

127.      Malakhova, M., et al. (2009) Structural diversity of the active N-terminal kinase domain of p90 ribosomal S6 kinase 2. PLoS One, 4, e8044.

128.      Lee, K.M., et al. (2009) Tpl2 is a key mediator of arsenite-induced signal transduction. Cancer Res, 69, 8043-9.

129.      Kwon, J.Y., et al. (2009) Delphinidin suppresses ultraviolet B-induced cyclooxygenases-2 expression through inhibition of MAPKK4 and PI-3 kinase. Carcinogenesis, 30, 1932-40.

130.      Kang, N.J., et al. (2009) Caffeic acid, a phenolic phytochemical in coffee, directly inhibits Fyn kinase activity and UVB-induced COX-2 expression. Carcinogenesis, 30, 321-30.

131.      Jeong, C.H., et al. (2009) [6]-Gingerol suppresses colon cancer growth by targeting leukotriene A4 hydrolase. Cancer Res, 69, 5584-91.

132.      Choi, H.S., et al. (2009) c-Jun N-terminal kinase 1 phosphorylates Myt1 to prevent UVA-induced skin cancer. Molecular and cellular biology, 29, 2168-80.

133.      Cho, Y.Y., et al. (2009) A regulatory mechanism for RSK2 NH(2)-terminal kinase activity. Cancer Res, 69, 4398-406.

134.      Cho, Y.Y., et al. (2009) Cyclin-dependent kinase-3-mediated c-Jun phosphorylation at Ser63 and Ser73 enhances cell transformation. Cancer Res, 69, 272-81.

135.      Bode, A.M., et al. (2009) Modulation of Cell Signal Transduction by Tea and Ginger. In Surh, Y.-J., et al. (eds.), Dietary Modulation of Cell Signaling Pathways. CRC Press–Taylor & Francis Group, New York, pp. 45-74.

136.      Bode, A.M., et al. (2009) Signal transduction molecules as targets for cancer prevention. Sci Signal, 2, mr2.

137.      Bode, A.M., et al. (2009) Epigallocatechin 3-gallate and green tea catechins: United they work, divided they fail. Cancer Prev Res (Phila Pa), 2, 514-7.

138.      Bode, A.M., et al. (2009) Cancer prevention research – then and now. Nat Rev Cancer, 9, 508-16.

139.      Bode, A.M., et al. (2009) Transient receptor potential type vanilloid 1 suppresses skin carcinogenesis. Cancer Res, 69, 905-13.

140.      Bode, A.M. (2009) In pursuit of a cure: Searching for food-based cancer therapies and preventions at The Hormel Institute. Rural Minnesota Journal, 4, 107-115.

141.      Zykova, T.A., et al. (2008) Resveratrol directly targets COX-2 to inhibit carcinogenesis. Molecular carcinogenesis, 47, 797-805.

142.      Zheng, D., et al. (2008) Cyclin-dependent kinase 3-mediated activating transcription factor 1 phosphorylation enhances cell transformation. Cancer Res, 68, 7650-60.

143.      Zheng, D., et al. (2008) The cannabinoid receptors are required for ultraviolet-induced inflammation and skin cancer development. Cancer Res, 68, 3992-8.

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