Ewa completed her undergraduate studies in Biology and Psychology at the University of Warsaw in Poland. In 2016 she obtained a Ph.D. in Hematology from the University of Cambridge in the United Kingdom, where she used functional genomics approaches to identify new genes involved in blood formation and disease.
She completed her postdoctoral training at Stanford University in the Department of Chemical and Systems Biology and in the Division of Cardiovascular Medicine at the Stanford University School of Medicine. During that time, she became interested in molecular metabolism and using functional genomics to identify new regulators of metabolic disease. In 2024, Ewa joined The Hormel Institute as an Assistant Professor.
Education
- 2016-2023 Postdoctoral training, Stanford University, CA
- 2016 Ph.D., Department of Hematology, University of Cambridge, UK
- 2011 M.Sc. in Biology and M.Sc. in Psychology, University of Warsaw, Poland
- 2009 B.Sc. in Biology, University of Warsaw, Poland
Professional memberships
- 2024- Member, American Diabetes Association
- 2016- Member, American Heart Association
Research Interests
- Metabolism
- Type 2 diabetes
- Functional genomics
- G protein-coupled receptors
Awards
- 2022: Pilot and Feasibility Award, Stanford Diabetes Research Center
- 2022: The Katharine McCormick Advanced Postdoctoral Scholar Fellowship to Support Women in Academic Medicine
- 2018-2020: Postdoctoral fellowship, American Heart Association
- 2019: Mansour Travel Award, Department of Chemical and Systems Biology, Stanford University
- 2018: Travel fellowship, Helena Anna Henzl-Gabor Young Women in Science Fund for Postdoctoral Scholars, Stanford University
- 2017: Stanford Center for Systems Biology seed grant
- 2016-2017: Dean’s postdoctoral fellowship, Stanford University
- 2011-2015: PhD fellowship, Wellcome Trust, United Kingdom
- 2013: Young Investigator Award, XXIV Congress of the International Society on Thrombosis and Haemostasis
Publications
1. Bielczyk-Maczynska E.*¶, Sharma D.*, Blencowe M., Saliba Gustafsson P., Gloudemans M., Yang X., Carcamo-Orive I., Wabitsch M., Svensson K.J., Park C.Y., Quertermous T., Knowles J.W.¶, Li J.* (2023) A single-cell CRISPRi platform for characterizing candidate genes relevant to metabolic disorders in human adipocytes. American Journal of Physiology-Cell Physiology, 325:C648-C660.
2. Li J.*, Jin C.*, Gustafsson S., Rao A., Wabitsch M., Park C.Y., Quertermous T., Knowles J.W.¶, Bielczyk-Maczynska E.¶ (2023) Single-cell transcriptome dataset of human and mouse in vitro adipogenesis models. Scientific Data, 10:387.
3. Bielczyk-Maczynska E.¶, Zhao M., Zushin P.J.H., Schnurr T.M., Kim H.J., Li J., Nallagatla P., Sangwung P., Park C., Cornn C., Stahl A., Svensson K.J., Knowles J.W.¶ (2022) G-protein coupled receptor 151 regulates glucose metabolism and hepatic gluconeogenesis. Nature Communications, 13:7408.
4. Zhao M., Dannieskiold-Samsoe N.B., Ulicnaa L., Nguyen Q., Voilquin L., Lee D.E., White J.P., Jiang Z., Cuthbert N., Paramasivam S., Bielczyk-Maczynska E., van Rechem C., Svensson K.J. (2022) Phosphoproteomic mapping reveals distinct signaling actions and activation of protein synthesis and muscle hypertrophy by Isthmin-1. eLife, 11:e80014.
5. Tholen S., Patel R., Agas A., Kovary K.M., Rabiee A., Nicholls H.T., Bielczyk-Maczynska E., Yang W., Kraemer F.B., Teruel M.N. (2022) Flattening of circadian glucocorticoid oscillations drives acute hyperinsulinemia and adipocyte hypertrophy. Cell Reports, 39(13): 111018.
6. Taylor B., Shah A., Bielczyk-Maczynska E.¶ (2020) TGF-β is insufficient to induce adipocyte state loss without concurrent PPARγ downregulation. Scientific Reports, 10(1): 1-13.
7. Bielczyk-Maczynska E.¶ (2019) White Adipocyte Plasticity in Physiology and Disease. Cells, 8(12): 1507.
8. Botthof J.G., Bielczyk-Maczynska E., Ferreira L., Cvejic A. (2017) Loss of the homologous recombination gene rad51 leads to Fanconi anemia-like symptoms in zebrafish. Proceedings of the National Academy of Sciences of the United States of America, 114(22): E4452-E4461.
9. Bielczyk-Maczynska E.*, Lam Hung L.*, Ferreira L., Fleischmann T., Weis F., Fernández-Pevida A., Harvey S.A., Wali N., Warren A.J., Barroso I., Stemple D.L., Cvejic A. (2015) The ribosome biogenesis protein Nol9 is essential for definitive hematopoiesis and pancreas morphogenesis in zebrafish. PLoS Genetics, 11(12): e1005677.
10. Chen L., Kostadima M., Martens J.H.A., Canu G., Garcia S.P., Turro E., Downes K., Macaulay I.C., Bielczyk-Maczynska E., Coe S., Farrow S., Poudel P., Burden F., Jansen S.B.G., Astle W.J., Attwood A., Bariana T., de Bono B., Breschi A., Chambers J.C., Bridge Consortium, Choudry F.A., Clarke L., Coupland P., van der Ent M., Erber W.N., Jansen J.H., Favier R., Fenech M.E., Foad N., Freson K., van Geet C., Gomez K., Guigo R., Hampshire D., Kelly A.M., Kerstens H.H.D., Kooner J.S., Laffan M., Lentaigne C., Labalette C., Martin T., Meacham S., Mumford A., Nürnberg S.T., Palumbo E., van der Reijden B.A., Richardson D., Sammut S.J., Slodkowicz G., Tamuri A.U., Vasquez L., Voss K., Watt S., Westbury S., Flicek P., Loos R., Goldman N., Bertone P., Read R.J., Richardson S., Cvejic A., Soranzo N., Ouwehand W.H., Stunnenberg H.G., Frontini M., Rendon A. (2014) Transcriptional diversity during lineage commitment of human blood progenitors. Science, 345(6204): 1251033.
11. Bielczyk-Maczynska E., Serbanovic-Canic J., Ferreira L., Soranzo N., Stemple D.L., Ouwehand W.H., Cvejic A. (2014) A loss of function screen of identified genome-wide study loci reveals new genes controlling hematopoiesis. PLoS Genetics, 10(7): e1004450.
12. Cvejic A., Haer-Wigman L., Stephens J., Kostadima M., Smethurst P., Frontini M., van den Akker E., Bertone P., Bielczyk-Maczynska E., Farrow S., Fehrmann R.S.N, Gray A., de Haas M., Haver V.G., Jordan G., Karjalainen J., Kerstens H.H.D., Kiddle G., Lloyd-Jones H., Needs M., Poole J., Soussan A.A., Rendon A., Rieneck K., Sambrook J.G., Schepers H., Silljé H.H.W., Sipos B., Swinkels D., Tamuri A.U., Verweij N., Watkins N.A., Westra H.J., Stemple D., Franke L., Soranzo N., Stunnenberg H.G., Goldman N., van der Harst P., van der Schoot C.E., Ouwehand W.H., Albers C.A. (2013) SMIM1 underlies the Vel blood group and influences red blood cell traits. Nature Genetics, doi:10.1038/ng.2603.
13. Bielczyk E.¶ (2010) [Imprinting on humans in selected animal species]. KOSMOS, 59(3-4), 451-457.
* These authors contributed equally / ¶ Corresponding author